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dc.creatorStefanović, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorVujović, Ana
dc.creatorSpasić, Slavica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.creatorMartinović, Jelena
dc.creatorArdalić, Daniela
dc.creatorMandić-Marković, Vesna
dc.creatorMiković, Željko
dc.creatorCerović, Nikola
dc.date.accessioned2019-09-02T11:27:20Z
dc.date.available2019-09-02T11:27:20Z
dc.date.issued2012
dc.identifier.issn1434-6621
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1635
dc.description.abstractBackground: Pregnancy is a stressful condition linked with altered lipid profile, increased oxidative stress and increased inflammation processes. The purpose of the present study was to determine the associations between those alterations with increased weight gain during pregnancy. Methods: The atherogenic index of plasma (AIP) and oxidative stress status parameters were determinated in 50 healthy and 172 pregnant women with non-complicated pregnancy. Pregnant women were divided in four groups according to body mass index (BMI) values (BMI quartiles). Results: Oxidative stress parameters were significantly lower in the control group compared with all the pregnant women quartiles. Unexpectedly, differences in oxidative stress parameters between BMI quartiles groups were not significant. The antioxidant defence parameters remained quite similar in the different BMI quartiles. Weight gain and paraoxonase-1 (PON1) activities were independently associated with increased AIP while weight gain and triglyceride concentration were found to be significant predictors of PON1 activities. Conclusions: The results of our current study indicate the association of maternal weight gain during pregnancy and altered lipid profile, elevated oxidative stress and changed antioxidative capacity of PON1. Taken together all these facts indicate possible increased risk of cardiovascular disease (CVD) development in later life if the weight gain during pregnancy is excessive.en
dc.publisherWalter de Gruyter Gmbh, Berlin
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Chemistry and Laboratory Medicine
dc.subjectatherogenic index of plasmaen
dc.subjectoxidative stressen
dc.subjectparaoxonase-1 pregnancyen
dc.titleAssociation of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Стефановић, Aлександра; Спасојевић-Калимановска, Весна; Вујовић, Aна; Миковић, Жељко; Церовић, Никола; Мандић-Марковић, Весна; Спасић, Славица; Aрдалић, Даниела; Котур-Стевуљевић, Јелена; Мартиновић, Јелена;
dc.citation.volume50
dc.citation.issue11
dc.citation.spage2019
dc.citation.epage2025
dc.citation.other50(11): 2019-2025
dc.citation.rankM21
dc.identifier.wos000310695300022
dc.identifier.doi10.1515/cclm-2012-0117
dc.identifier.pmid23093082
dc.identifier.scopus2-s2.0-84872949637
dc.identifier.rcubconv_2720
dc.type.versionpublishedVersion


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