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Drug use before and during pregnancy in Serbia

Authorized Users Only
2012
Authors
Odalović, Marina
Vezmar-Kovačević, Sandra
Ilić, Katarina
Sabo, Ana
Tasić, Ljiljana
Article (Published version)
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Abstract
Background Observation of drug use patterns during pregnancy is necessary for the recognition of potential bad practices and improvement of safe drug use in pregnancy. Objective To investigate prescription and over the counter drug use among Serbian women in the 6 months before pregnancy and in the first 6 months of pregnancy, and to evaluate the drugs used according to the risk to a fetus. Setting Six maternity care units and five community pharmacies Method A multi-center study was performed in Serbia during the period from March 2009-March 2010. A self-reporting questionnaire was used as a data source. Food and Drug Administration (FDA) risk classification system was used to determine the risk of used drugs for the fetus. Differences between subgroups were assessed using McNemar's test on paired proportions. Main outcome measure Proportion of women exposed to drugs or class of drugs. Results The overall drug exposure was higher in pregnancy (34.7 %) than before pregnancy (29.9 %), p... > 0.05, in the cohort of 311 pregnant women. A significantly greater prescription drug use, 19.0 versus 27.3 % of women, p lt 0.05, and less selfmedication with over the counter drugs in pregnancy, 15.1 versus 8.7 %, p lt 0.05, were observed. Commonly used drugs were musculoskeletal drugs, analgesics/antipyretics and respiratory system drugs before pregnancy (13.8, 12.5, and 6.4 % of women, respectively), and progestogens, analgesics/antipyretics, and antibiotics for the systemic use in pregnancy (9.0, 7.7, and 7.4 %, respectively). A greater exposure to drugs belonging to the FDA risk category A (3.9 vs. 60.8 %, p lt 0.05), B (18.0 vs. 19.6 %, p > 0.05), C (10.0 vs. 10.3 %, p > 0.05) and D (2.9 vs. 10.9 %, p lt 0.05), as well as less exposure to drugs belonging to category X (0.3 vs. 0 %, p > 0.05) were observed in pregnancy. Folic acid was used by 60.8 % of women in pregnancy, and by only 3.9 % before pregnancy. Conclusion Besides higher overall drug use in pregnancy than before pregnancy, particularly the use of progestogens, and, subsequently, D category drugs, less selfmedication with over the counter drugs was observed in pregnancy. Insufficient use of folic acid before pregnancy requires public health service activities.

Keywords:
Drug use / FDA pregnancy risk classification / OTC medication / Pregnancy / Serbia
Source:
International Journal of Clinical Pharmacy, 2012, 34, 5, 719-727
Publisher:
  • Springer, Dordrecht
Funding / projects:
  • The interaction of xenobiotics with biological systems (RS-41012)

DOI: 10.1007/s11096-012-9665-8

ISSN: 2210-7703

PubMed: 22744842

WoS: 000309676500009

Scopus: 2-s2.0-84867400463
[ Google Scholar ]
20
17
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1636
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Odalović, Marina
AU  - Vezmar-Kovačević, Sandra
AU  - Ilić, Katarina
AU  - Sabo, Ana
AU  - Tasić, Ljiljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1636
AB  - Background Observation of drug use patterns during pregnancy is necessary for the recognition of potential bad practices and improvement of safe drug use in pregnancy. Objective To investigate prescription and over the counter drug use among Serbian women in the 6 months before pregnancy and in the first 6 months of pregnancy, and to evaluate the drugs used according to the risk to a fetus. Setting Six maternity care units and five community pharmacies Method A multi-center study was performed in Serbia during the period from March 2009-March 2010. A self-reporting questionnaire was used as a data source. Food and Drug Administration (FDA) risk classification system was used to determine the risk of used drugs for the fetus. Differences between subgroups were assessed using McNemar's test on paired proportions. Main outcome measure Proportion of women exposed to drugs or class of drugs. Results The overall drug exposure was higher in pregnancy (34.7 %) than before pregnancy (29.9 %), p > 0.05, in the cohort of 311 pregnant women. A significantly greater prescription drug use, 19.0 versus 27.3 % of women, p  lt  0.05, and less selfmedication with over the counter drugs in pregnancy, 15.1 versus 8.7 %, p  lt  0.05, were observed. Commonly used drugs were musculoskeletal drugs, analgesics/antipyretics and respiratory system drugs before pregnancy (13.8, 12.5, and 6.4 % of women, respectively), and progestogens, analgesics/antipyretics, and antibiotics for the systemic use in pregnancy (9.0, 7.7, and 7.4 %, respectively). A greater exposure to drugs belonging to the FDA risk category A (3.9 vs. 60.8 %, p  lt  0.05), B (18.0 vs. 19.6 %, p > 0.05), C (10.0 vs. 10.3 %, p > 0.05) and D (2.9 vs. 10.9 %, p  lt  0.05), as well as less exposure to drugs belonging to category X (0.3 vs. 0 %, p > 0.05) were observed in pregnancy. Folic acid was used by 60.8 % of women in pregnancy, and by only 3.9 % before pregnancy. Conclusion Besides higher overall drug use in pregnancy than before pregnancy, particularly the use of progestogens, and, subsequently, D category drugs, less selfmedication with over the counter drugs was observed in pregnancy. Insufficient use of folic acid before pregnancy requires public health service activities.
PB  - Springer, Dordrecht
T2  - International Journal of Clinical Pharmacy
T1  - Drug use before and during pregnancy in Serbia
VL  - 34
IS  - 5
SP  - 719
EP  - 727
DO  - 10.1007/s11096-012-9665-8
ER  - 
@article{
author = "Odalović, Marina and Vezmar-Kovačević, Sandra and Ilić, Katarina and Sabo, Ana and Tasić, Ljiljana",
year = "2012",
abstract = "Background Observation of drug use patterns during pregnancy is necessary for the recognition of potential bad practices and improvement of safe drug use in pregnancy. Objective To investigate prescription and over the counter drug use among Serbian women in the 6 months before pregnancy and in the first 6 months of pregnancy, and to evaluate the drugs used according to the risk to a fetus. Setting Six maternity care units and five community pharmacies Method A multi-center study was performed in Serbia during the period from March 2009-March 2010. A self-reporting questionnaire was used as a data source. Food and Drug Administration (FDA) risk classification system was used to determine the risk of used drugs for the fetus. Differences between subgroups were assessed using McNemar's test on paired proportions. Main outcome measure Proportion of women exposed to drugs or class of drugs. Results The overall drug exposure was higher in pregnancy (34.7 %) than before pregnancy (29.9 %), p > 0.05, in the cohort of 311 pregnant women. A significantly greater prescription drug use, 19.0 versus 27.3 % of women, p  lt  0.05, and less selfmedication with over the counter drugs in pregnancy, 15.1 versus 8.7 %, p  lt  0.05, were observed. Commonly used drugs were musculoskeletal drugs, analgesics/antipyretics and respiratory system drugs before pregnancy (13.8, 12.5, and 6.4 % of women, respectively), and progestogens, analgesics/antipyretics, and antibiotics for the systemic use in pregnancy (9.0, 7.7, and 7.4 %, respectively). A greater exposure to drugs belonging to the FDA risk category A (3.9 vs. 60.8 %, p  lt  0.05), B (18.0 vs. 19.6 %, p > 0.05), C (10.0 vs. 10.3 %, p > 0.05) and D (2.9 vs. 10.9 %, p  lt  0.05), as well as less exposure to drugs belonging to category X (0.3 vs. 0 %, p > 0.05) were observed in pregnancy. Folic acid was used by 60.8 % of women in pregnancy, and by only 3.9 % before pregnancy. Conclusion Besides higher overall drug use in pregnancy than before pregnancy, particularly the use of progestogens, and, subsequently, D category drugs, less selfmedication with over the counter drugs was observed in pregnancy. Insufficient use of folic acid before pregnancy requires public health service activities.",
publisher = "Springer, Dordrecht",
journal = "International Journal of Clinical Pharmacy",
title = "Drug use before and during pregnancy in Serbia",
volume = "34",
number = "5",
pages = "719-727",
doi = "10.1007/s11096-012-9665-8"
}
Odalović, M., Vezmar-Kovačević, S., Ilić, K., Sabo, A.,& Tasić, L.. (2012). Drug use before and during pregnancy in Serbia. in International Journal of Clinical Pharmacy
Springer, Dordrecht., 34(5), 719-727.
https://doi.org/10.1007/s11096-012-9665-8
Odalović M, Vezmar-Kovačević S, Ilić K, Sabo A, Tasić L. Drug use before and during pregnancy in Serbia. in International Journal of Clinical Pharmacy. 2012;34(5):719-727.
doi:10.1007/s11096-012-9665-8 .
Odalović, Marina, Vezmar-Kovačević, Sandra, Ilić, Katarina, Sabo, Ana, Tasić, Ljiljana, "Drug use before and during pregnancy in Serbia" in International Journal of Clinical Pharmacy, 34, no. 5 (2012):719-727,
https://doi.org/10.1007/s11096-012-9665-8 . .

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