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dc.creatorMilinković, Neda
dc.creatorMajkić-Singh, Nada
dc.creatorIgnjatović, Svetlana
dc.creatorLezaić, Višnja D.
dc.creatorPejanović, Svetlana D.
dc.creatorJovanović, Dijana B.
dc.date.accessioned2019-09-02T11:27:26Z
dc.date.available2019-09-02T11:27:26Z
dc.date.issued2012
dc.identifier.issn1433-6510
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1638
dc.description.abstractBackground: Bone alkaline phosphatase (BALP) is a direct and independent indicator of impaired bone turnover. We intended to find out whether there are any significant changes in BALP and iPTH levels, in comparison to total Ca, total Mg, inorganic P, total alkaline phosphatase (ALP), and tartrate resistant acid phosphatase (TRAP) in predialysis and dialysis patients. Methods: Out of 266 patients investigated, 114 were on continuous ambulatory peritoneal dialysis, 112 were on maintenance haemodialysis, while 40 predialysis patients had end stage renal disease. The parameters were analysed according to the manufacturers' instructions. Results: Correlations were established for the bone marker concentrations analysed among the studied groups. The largest ranges were determined for BALP and iPTH. Predialysis and dialysis patients showed very low levels of BALP. Dialysis patients had lower levels of iPTH (p lt 0.001), while in predialysis patients the levels were significantly higher (p lt 0.05) than recommended for low bone turnover, according to K/DOQI. Conclusions: The observations made in this study identify BALP as a good indicator of decreased bone turnover in predialysis and dialysis patients. However, in order to reveal a difference between bone activity and the level of parathyroid activity and its effect on bone turnover, it is always necessary to observe both BALP and iPTH levels. (Clin. Lab. 2012;58:747-753. DOI: 10.7754/Clin.Lab.2011.110816)en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjectBiochemical markersen
dc.subjectbone alkaline phosphataseen
dc.subjectdialysisen
dc.subjectparathyroid hormoneen
dc.subjectrenal osteodystrophyen
dc.titleCorrelation of Bone Alkaline Phosphatase and iPTH with Some Basic Biochemical Markers in Predialysis and Dialysis Patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПејановић, Светлана Д.; Игњатовић, Светлана; Мајкић-Сингх, Нада; Милинковић, Неда; Лезаић, Вишња Д.; Јовановић, Дијана Б.;
dc.citation.volume58
dc.citation.issue7-8
dc.citation.spage747
dc.citation.epage753
dc.citation.other58(7-8): 747-753
dc.citation.rankM23
dc.identifier.wos000308385700015
dc.identifier.doi10.7754/Clin.Lab.2011.110816
dc.identifier.pmid22997975
dc.identifier.scopus2-s2.0-84866117866
dc.type.versionpublishedVersion


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