Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release
Abstract
The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery system (SMEDDS) was formulated using the surfactant polyoxyethylene 20 sorbitan monooleate [Polysorbate 80] (S), the cosurfactant PEG-40 hydrogenated castor oil [Cremophor (R) RH40]
Keywords:
Solid self-microemulsifying drug delivery systems / Magnesium aluminometasilicate / Porous silica / Carbamazepine / Dissolution rate improvementSource:
International Journal of Pharmaceutics, 2012, 436, 1-2, 58-65Publisher:
- Elsevier Science BV, Amsterdam
Projects:
- Ministry of Education and Science, Republic of Serbia
DOI: 10.1016/j.ijpharm.2012.06.032
ISSN: 0378-5173
PubMed: 22721847