Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release

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2012
Authors
Milović, Mladen
Đuriš, Jelena
Đekić, Ljiljana
Vasiljević, Dragana
Ibrić, Svetlana
Article (Published version)
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Abstract
The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery system (SMEDDS) was formulated using the surfactant polyoxyethylene 20 sorbitan monooleate [Polysorbate 80] (S), the cosurfactant PEG-40 hydrogenated castor oil [Cremophor (R) RH40]
Keywords:
Solid self-microemulsifying drug delivery systems / Magnesium aluminometasilicate / Porous silica / Carbamazepine / Dissolution rate improvement
Source:
International Journal of Pharmaceutics, 2012, 436, 1-2, 58-65
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Ministry of Education and Science, Republic of Serbia

DOI: 10.1016/j.ijpharm.2012.06.032

ISSN: 0378-5173

PubMed: 22721847

WoS: 000308597600006

Scopus: 2-s2.0-84865284761
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1639
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Pharmacy