Приказ основних података о документу

dc.creatorOdović, Jadranka
dc.creatorKarljiković-Rajić, Katarina
dc.creatorTrbojević-Stanković, Jasna
dc.creatorStojimirović, Biljana
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:27:30Z
dc.date.available2019-09-02T11:27:30Z
dc.date.issued2012
dc.identifier.issn1735-0328
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1642
dc.description.abstractIn this assay, the evaluation of lipophilicity of four ACE-inhibitors and hydrochlorothiazide (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with HCTZ. In addition, the linear relationship between the R-M-values and composition of mobile phases was established in the current study. From the regression data of the plots, the hydrophobicity parameters, R-M(0) and m, were determined and C-0 parameter was calculated. The correlations between the experimentally obtained hydrophobicity parameters and calculated log p values were studied. Furthermore, the obtained results were compared with those previously obtained on RP-18 modified silica gel. Very good correlation (r = 0.91; water-ethanol solvent system) between the chromatographically obtained hydrophobicity parameters and calculated log p values confirmed the selection of ACE inhibitors since lisinopril and quinapril were on the opposite sites of linear relationship. The results indicate that cellulose as an easily available sorbent can be successfully used for the lipophilicity investigation of examined substances with RP-TLC.en
dc.publisherShaheed Beheshti Univ, Sch Pharmacy, Tehran
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceIranian Journal of Pharmaceutical Research
dc.subjectLipophilicityen
dc.subjectACE inhibitorsen
dc.subjectHydrochlorothiazideen
dc.subjectThin-Layer Chromatographyen
dc.titleThe Lipophilicity Examination of Some ACE inhibitors and Hydrochlorothiazide on Cellulose in RP Thin-Layer Chromatographyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВладимиров, Соте; Одовић, Јадранка; Трбојевић-Станковић, Јасна; Стојимировић, Биљана; Карљиковић-Рајић, Катарина;
dc.citation.volume11
dc.citation.issue3
dc.citation.spage763
dc.citation.epage770
dc.citation.other11(3): 763-770
dc.citation.rankM23
dc.identifier.wos000308794400008
dc.identifier.pmid24250503
dc.identifier.scopus2-s2.0-84865198922
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_1642
dc.type.versionpublishedVersion


Документи

ДатотекеВеличинаФорматПреглед

Уз овај запис нема датотека.

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу