Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation
Само за регистроване кориснике
2012
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential ...were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.
Кључне речи:
alkyl polyglucoside-mixed emulsifiers / antioxidants / cosmeceuticals / in vivo skin performance / lactobionic acidИзвор:
International Journal of Cosmetic Science, 2012, 34, 5, 424-434Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
DOI: 10.1111/j.1468-2494.2012.00732.x
ISSN: 0142-5463
PubMed: 22691034
WoS: 000308871300005
Scopus: 2-s2.0-84866364732
Институција/група
PharmacyTY - JOUR AU - Tasić-Kostov, Marija AU - Pavlović, Dragana R. AU - Lukić, Milica AU - Jaksić, I. AU - Arsić, I. AU - Savić, Snežana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1643 AB - Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle. PB - Wiley-Blackwell, Hoboken T2 - International Journal of Cosmetic Science T1 - Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation VL - 34 IS - 5 SP - 424 EP - 434 DO - 10.1111/j.1468-2494.2012.00732.x ER -
@article{ author = "Tasić-Kostov, Marija and Pavlović, Dragana R. and Lukić, Milica and Jaksić, I. and Arsić, I. and Savić, Snežana", year = "2012", abstract = "Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.", publisher = "Wiley-Blackwell, Hoboken", journal = "International Journal of Cosmetic Science", title = "Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation", volume = "34", number = "5", pages = "424-434", doi = "10.1111/j.1468-2494.2012.00732.x" }
Tasić-Kostov, M., Pavlović, D. R., Lukić, M., Jaksić, I., Arsić, I.,& Savić, S.. (2012). Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation. in International Journal of Cosmetic Science Wiley-Blackwell, Hoboken., 34(5), 424-434. https://doi.org/10.1111/j.1468-2494.2012.00732.x
Tasić-Kostov M, Pavlović DR, Lukić M, Jaksić I, Arsić I, Savić S. Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation. in International Journal of Cosmetic Science. 2012;34(5):424-434. doi:10.1111/j.1468-2494.2012.00732.x .
Tasić-Kostov, Marija, Pavlović, Dragana R., Lukić, Milica, Jaksić, I., Arsić, I., Savić, Snežana, "Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation" in International Journal of Cosmetic Science, 34, no. 5 (2012):424-434, https://doi.org/10.1111/j.1468-2494.2012.00732.x . .