Приказ основних података о документу

dc.creatorTasić-Kostov, Marija
dc.creatorPavlović, Dragana R.
dc.creatorLukić, Milica
dc.creatorJaksić, I.
dc.creatorArsić, I.
dc.creatorSavić, Snežana
dc.date.accessioned2019-09-02T11:27:34Z
dc.date.available2019-09-02T11:27:34Z
dc.date.issued2012
dc.identifier.issn0142-5463
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1643
dc.description.abstractSynopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45017/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Cosmetic Science
dc.subjectalkyl polyglucoside-mixed emulsifiersen
dc.subjectantioxidantsen
dc.subjectcosmeceuticalsen
dc.subjectin vivo skin performanceen
dc.subjectlactobionic aciden
dc.titleLactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПавловић, Драгана Р.; Лукић, Милица; Јаксић, И.; Савић, Снежана; Aрсић, И.; Тасић-Костов, Марија;
dc.citation.volume34
dc.citation.issue5
dc.citation.spage424
dc.citation.epage434
dc.citation.other34(5): 424-434
dc.identifier.wos000308871300005
dc.identifier.doi10.1111/j.1468-2494.2012.00732.x
dc.identifier.pmid22691034
dc.identifier.scopus2-s2.0-84866364732
dc.type.versionpublishedVersion


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Приказ основних података о документу