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Demasking large dummy effects approach in revealing important interactions in Plackett-Burman experimental design

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2012
Authors
Rakić, Tijana
Jančić-Stojanović, Biljana
Malenović, Anđelija
Ivanović, Darko
Medenica, Mirjana
Article (Published version)
Metadata
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Abstract
This paper presents a newly developed demasking large dummy effects (DDE) approach for identification of significant factor interactions in Plackett-Burman experimental design. Dummy factors, as imaginary factors, are not expected to contribute to the model, so the appearance of their high effect values could indicate the significance of the interactions they are confounded with. DDE approach consists of the screening of the large estimable effects, the calculation of the interactions that contribute the most to the large dummy effects from the alias matrix, and a single pass of all subsets regressions including preselected interactions and main factors for the final model tuning. Tested on experimentally obtained data from a robustness analysis of a method for the determination of raloxifene and its four impurities, DDE approach showed to create the models that have greater statistical power than the ones described with the main factors only, which makes them more reliable and accurat...e for the application. Additionally, because of the interactions selection criterion and final tuning phase of the strategy, DDE approach allows the creation of models that are likely to better describe the real systems, which increases the practical value. Copyright

Keywords:
demasking large dummy effects (DDE) approach / Plackett-Burman design / robustness / all subsets regressions / raloxifene
Source:
Journal of Chemometrics, 2012, 26, 10, 518-525
Publisher:
  • Wiley, Hoboken
Projects:
  • Modelling of different chromatographic systems with chemometrical approach in pharmaceutical analysis (RS-172052)

DOI: 10.1002/cem.2461

ISSN: 0886-9383

WoS: 000312547700003

Scopus: 2-s2.0-84867332795
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1646
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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