Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players
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2012
Authors
Đorđević, Brižita
Baralić, Ivana
Kotur-Stevuljević, Jelena

Stefanović, Aleksandra

Ivanišević, Jasmina

Radivojević, Nenad
Anđelković, Marija
Dikić, Nenad

Article (Published version)

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Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center... dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players
Keywords:
Astaxanthine / Soccer / Oxidative stressSource:
Journal of Sports Medicine and Physical Fitness, 2012, 52, 4, 382-392Publisher:
- Edizioni Minerva Medica, Turin
Funding / projects:
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
- Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)
- Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-46001)
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PharmacyTY - JOUR AU - Đorđević, Brižita AU - Baralić, Ivana AU - Kotur-Stevuljević, Jelena AU - Stefanović, Aleksandra AU - Ivanišević, Jasmina AU - Radivojević, Nenad AU - Anđelković, Marija AU - Dikić, Nenad PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1654 AB - Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players PB - Edizioni Minerva Medica, Turin T2 - Journal of Sports Medicine and Physical Fitness T1 - Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players VL - 52 IS - 4 SP - 382 EP - 392 UR - https://hdl.handle.net/21.15107/rcub_farfar_1654 ER -
@article{ author = "Đorđević, Brižita and Baralić, Ivana and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Ivanišević, Jasmina and Radivojević, Nenad and Anđelković, Marija and Dikić, Nenad", year = "2012", abstract = "Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players", publisher = "Edizioni Minerva Medica, Turin", journal = "Journal of Sports Medicine and Physical Fitness", title = "Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players", volume = "52", number = "4", pages = "382-392", url = "https://hdl.handle.net/21.15107/rcub_farfar_1654" }
Đorđević, B., Baralić, I., Kotur-Stevuljević, J., Stefanović, A., Ivanišević, J., Radivojević, N., Anđelković, M.,& Dikić, N.. (2012). Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. in Journal of Sports Medicine and Physical Fitness Edizioni Minerva Medica, Turin., 52(4), 382-392. https://hdl.handle.net/21.15107/rcub_farfar_1654
Đorđević B, Baralić I, Kotur-Stevuljević J, Stefanović A, Ivanišević J, Radivojević N, Anđelković M, Dikić N. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. in Journal of Sports Medicine and Physical Fitness. 2012;52(4):382-392. https://hdl.handle.net/21.15107/rcub_farfar_1654 .
Đorđević, Brižita, Baralić, Ivana, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Ivanišević, Jasmina, Radivojević, Nenad, Anđelković, Marija, Dikić, Nenad, "Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players" in Journal of Sports Medicine and Physical Fitness, 52, no. 4 (2012):382-392, https://hdl.handle.net/21.15107/rcub_farfar_1654 .