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Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players

Authorized Users Only
2012
Authors
Đorđević, Brižita
Baralić, Ivana
Kotur-Stevuljević, Jelena
Stefanović, Aleksandra
Ivanišević, Jasmina
Radivojević, Nenad
Anđelković, Marija
Dikić, Nenad
Article (Published version)
Metadata
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Abstract
Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center... dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players

Keywords:
Astaxanthine / Soccer / Oxidative stress
Source:
Journal of Sports Medicine and Physical Fitness, 2012, 52, 4, 382-392
Publisher:
  • Edizioni Minerva Medica, Turin
Funding / projects:
  • Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)
  • Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-46001)

ISSN: 0022-4707

PubMed: 22828460

WoS: 000309377200007

Scopus: 2-s2.0-84867076898
[ Google Scholar ]
53
46
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1654
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1654
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Đorđević, Brižita
AU  - Baralić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Radivojević, Nenad
AU  - Anđelković, Marija
AU  - Dikić, Nenad
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1654
AB  - Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players
PB  - Edizioni Minerva Medica, Turin
T2  - Journal of Sports Medicine and Physical Fitness
T1  - Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players
VL  - 52
IS  - 4
SP  - 382
EP  - 392
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1654
ER  - 
@article{
author = "Đorđević, Brižita and Baralić, Ivana and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Ivanišević, Jasmina and Radivojević, Nenad and Anđelković, Marija and Dikić, Nenad",
year = "2012",
abstract = "Aim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer players",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Journal of Sports Medicine and Physical Fitness",
title = "Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players",
volume = "52",
number = "4",
pages = "382-392",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1654"
}
Đorđević, B., Baralić, I., Kotur-Stevuljević, J., Stefanović, A., Ivanišević, J., Radivojević, N., Anđelković, M.,& Dikić, N.. (2012). Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. in Journal of Sports Medicine and Physical Fitness
Edizioni Minerva Medica, Turin., 52(4), 382-392.
https://hdl.handle.net/21.15107/rcub_farfar_1654
Đorđević B, Baralić I, Kotur-Stevuljević J, Stefanović A, Ivanišević J, Radivojević N, Anđelković M, Dikić N. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. in Journal of Sports Medicine and Physical Fitness. 2012;52(4):382-392.
https://hdl.handle.net/21.15107/rcub_farfar_1654 .
Đorđević, Brižita, Baralić, Ivana, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Ivanišević, Jasmina, Radivojević, Nenad, Anđelković, Marija, Dikić, Nenad, "Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players" in Journal of Sports Medicine and Physical Fitness, 52, no. 4 (2012):382-392,
https://hdl.handle.net/21.15107/rcub_farfar_1654 .

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