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dc.creatorĐorđević, Brižita
dc.creatorBaralić, Ivana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorStefanović, Aleksandra
dc.creatorIvanišević, Jasmina
dc.creatorRadivojević, Nenad
dc.creatorAnđelković, Marija
dc.creatorDikić, Nenad
dc.date.accessioned2019-09-02T11:27:49Z
dc.date.available2019-09-02T11:27:49Z
dc.date.issued2012
dc.identifier.issn0022-4707
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1654
dc.description.abstractAim. The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Methods. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. After the 90 days of supplementation, the athletes performed a 2 hour acute exercise bout. Blood samples were obtained before and after 90 days of supplementation and after the exercise at the end of observational period for analysis of thiobarbituric acid-reacting substances (TBARS), advanced oxidation protein products (AOPP), superoxide anion (O-2(center dot-)), total antioxidative status (TAS), sulphydril groups (SH), superoxide-dismutase (SOD), serum creatine kinase (CK) and aspartate aminotransferase (AST). Results. TBARS and AOPP levels did not change throughout the study. Regular training significantly increased O-2(center dot-) levels (main training effect, P lt 0.01). O-2(center dot-) increased after the soccer exercise (main exercise effect, P lt 0.01), but these changes reached statistical significance only in the P group (exercise x supplementation effect, P lt 0.05). TAS levels decreased significantly post- exercise only in P group (P lt 0.01). Both Asx and P groups experienced increase in total SH groups content (by 21% and 9%, respectively) and supplementation effect was marginally significant (P=0.08). Basal SOD activity significantly decreased both in P and in Asx group by the end of the study (main training effect, P lt 0.01). All participants showed a significant decrease in basal CK and AST activities after 90 days (main training effect, P lt 0.01 and P lt 0.001, respectively). CK and AST activities in serum significantly increased as result of soccer exercise (main exercise effect, P lt 0.001 and P lt 0.01, respectively). Postexercise CK and AST levels were significantly lower in Asx group compared to P group (P lt 0.05) Conclusion. The results of the present study suggest that soccer training and soccer exercise are associated with excessive production of free radicals and oxidative stress, which might diminish antioxidant system efficiency. Supplementation with Asx could prevent exercise induced free radical production and depletion of non-enzymatic antioxidant defense in young soccer playersen
dc.publisherEdizioni Minerva Medica, Turin
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Sports Medicine and Physical Fitness
dc.subjectAstaxanthineen
dc.subjectSocceren
dc.subjectOxidative stressen
dc.titleEffect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer playersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнђелковић, Марија; Котур-Стевуљевић, Јелена; Стефановић, Aлександра; Дикић, Ненад; Иванишевић, Јасмина; Ђорђевић, Брижита; Баралић, Ивана; Радивојевић, Ненад;
dc.citation.volume52
dc.citation.issue4
dc.citation.spage382
dc.citation.epage392
dc.citation.other52(4): 382-392
dc.citation.rankM23
dc.identifier.wos000309377200007
dc.identifier.pmid22828460
dc.identifier.scopus2-s2.0-84867076898
dc.identifier.rcubconv_2700
dc.type.versionpublishedVersion


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