Приказ основних података о документу

dc.creatorDivljaković, Jovana
dc.creatorTimić, Tamara
dc.creatorMilinković, Marija M.
dc.creatorBatinić, Bojan
dc.creatorvan Linn, Michael
dc.creatorCook, James M.
dc.creatorSavić, Miroslav
dc.date.accessioned2019-09-02T11:27:57Z
dc.date.available2019-09-02T11:27:57Z
dc.date.issued2012
dc.identifier.issn1461-1457
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1661
dc.description.abstractObjective : Despite a half century of clinical use and the recognized potential of benzodiazepine dependence, the mechanisms under- lying benzodiazepine withdrawal remain insufficiently understood. The aim of the present study was to assess the influence of the non- selective antagonist (flumazenil) and the preferential a1-subunit selective antagonist (bCCt) on the anxiety level after diazepam with- drawal. Methods : The male Wistar rats were protractedly treated during 21 days with diazepam (2 mg/kg) or solvent. On the testing day, 24 hours after the last injection, animals from the diazepam-treated groups received either antagonist (flumazenil or bCCt) or solvent, and animals from the solvent-treated groups received solvent or diaze- pam. Twenty minutes after administration of treatment on the testing day, single animals were placed in the elevated plus maze in order to assess the level of anxiety. Results : Two-way ANOVA revealed that animals withdrawn from diazepam spent significantly less time on the open arms than control animals (p=0.023). One-way ANOVA, followed by post hoc test, re- vealed that administration of flumazenil (10 mg/kg) or bCCt (1.25, 5 or 20 mg/kg) reversed the diazepam withdrawal-induced anxiety (percentage of open arm time : p=0.003, p=0.032, p=0.031 and p=0.014 compared to the diazepam-withdrawn group, respectively). Concomitant administration of antagonists (10 mg/kg flumazenil, or 1.25, 5 or 20 mg/kg bCCt) induced an anxiolytic effect comparable to that observed after acutely administrated diazepam (percentage of open arm time : p=0.142, p=0.187, p=0.243 and p=0.290, respect- ively). Conclusion : The present study demonstrated that administration of the a1-selective antagonist bCCt or non-selective antagonist flumazenil could prevent the withdrawal-induced anxiety and also induce an anxiolytic-like effect. Moreover, presented results have suggested that mechanism of preventing the withdrawal-induced anxiety involves the antagonism at a1-containing GABAA receptors.
dc.publisherOxford Univ Press, Oxford
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceInternational Journal of Neuropsychopharmacology
dc.titleBeta CCT as well as flumazenil prevent the diazepam withdrawal-induced anxiety in the elevated plus maze in ratsen
dc.typeconferenceObject
dc.rights.licenseBY-NC
dcterms.abstractБатинић, Бојан; ван Линн, Мицхаел; Милинковић, Марија М.; Тимић, Тамара; Цоок, Јамес М.; Савић, Мирослав; Дивљаковић, Јована;
dc.citation.volume15
dc.citation.issueSupplement 1
dc.citation.spage201
dc.citation.epage201
dc.citation.other15: 201-201
dc.citation.rankaM21
dc.description.other28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012
dc.identifier.wos000209062500737
dc.identifier.doi10.1017/S1461145712000508
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/11552/bCCT_as_well_pub_2012.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_1661
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу