Tolerance liability of diazepam is dependent on the dose used for protracted treatment
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2012
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Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background: Behavioral effects of benzodiazepines following repeated exposure vary according to the intrinsic efficacy of the benzodiazepine studied, treatment schedule and the behavioral parameters evaluated. Methods: We applied the behavioral paradigms of spontaneous locomotor activity, elevated plus maze and grip strength to investigate the sedative, anxiolyfic and myorelaxant effect of acute challenge with 2 mg/kg diazepam administered after 14 days of protracted treatment with 0.5, 2 or 10 mg/kg of diazepam. In addition, we studied the effects of everyday handling and intraperitoneal (ip) administration on animal behavior. Results: Tolerance to the sedative effect of 2 mg/kg diszepam ensued after 14 days of protracted treatment with 2 and 10 mg/kg of diazepam. In contrast, treatment with the lowest dose (0.5 mg/kg) of diazepam resulted in potentiation of the sedative effect of acute challenge with 2 mg/kg diazepam thus confounding the detection of the anxiolytic effect of diazepam.... A sensitization-like response to the anxiolytic action of 2 mg/kg diazepam was seen after protracted treatment with the intermediate dose (2 mg/kg); however, anxiolytic effect was absent after protracted administration of the highest dose. Partial tolerance to the muscle relaxant effect of 2 mg/kg diazepam ensued after protracted treatment with diazepam regardless of the dose. Daily handling or ip administration did not alter the behavioral response to acute challenge with 2 mg/kg diazepam in all the three behavioral paradigms studied. Conclusion: The presented results showed that behavioral effects of acute challenge with diazepam were differently affected by the dose administered during protracted treatment.
Ključne reči:
spontaneous locomotor activity / elevated plus maze / grip strength / toleranceIzvor:
Pharmacological Reports, 2012, 64, 5, 1116-1125Izdavač:
- Polish Acad Sciences Inst Pharmacology, Krakow
Finansiranje / projekti:
- Bihejvioralni efekti ponavljane primene novosintetisanih supstanci selektivnih za pojedine podtipove benzodiazepinskog mesta vezivanja GABA A receptora: poređenje sa standardnim psihofarmakološkim lekovima (RS-MESTD-Basic Research (BR or ON)-175076)
DOI: 10.1016/S1734-1140(12)70908-8
ISSN: 1734-1140
PubMed: 23238468
WoS: 000208844100010
Scopus: 2-s2.0-84873737172
Institucija/grupa
PharmacyTY - JOUR AU - Divljaković, Jovana AU - Milić, Marija AU - Timić, Tamara AU - Savić, Miroslav PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1668 AB - Background: Behavioral effects of benzodiazepines following repeated exposure vary according to the intrinsic efficacy of the benzodiazepine studied, treatment schedule and the behavioral parameters evaluated. Methods: We applied the behavioral paradigms of spontaneous locomotor activity, elevated plus maze and grip strength to investigate the sedative, anxiolyfic and myorelaxant effect of acute challenge with 2 mg/kg diazepam administered after 14 days of protracted treatment with 0.5, 2 or 10 mg/kg of diazepam. In addition, we studied the effects of everyday handling and intraperitoneal (ip) administration on animal behavior. Results: Tolerance to the sedative effect of 2 mg/kg diszepam ensued after 14 days of protracted treatment with 2 and 10 mg/kg of diazepam. In contrast, treatment with the lowest dose (0.5 mg/kg) of diazepam resulted in potentiation of the sedative effect of acute challenge with 2 mg/kg diazepam thus confounding the detection of the anxiolytic effect of diazepam. A sensitization-like response to the anxiolytic action of 2 mg/kg diazepam was seen after protracted treatment with the intermediate dose (2 mg/kg); however, anxiolytic effect was absent after protracted administration of the highest dose. Partial tolerance to the muscle relaxant effect of 2 mg/kg diazepam ensued after protracted treatment with diazepam regardless of the dose. Daily handling or ip administration did not alter the behavioral response to acute challenge with 2 mg/kg diazepam in all the three behavioral paradigms studied. Conclusion: The presented results showed that behavioral effects of acute challenge with diazepam were differently affected by the dose administered during protracted treatment. PB - Polish Acad Sciences Inst Pharmacology, Krakow T2 - Pharmacological Reports T1 - Tolerance liability of diazepam is dependent on the dose used for protracted treatment VL - 64 IS - 5 SP - 1116 EP - 1125 DO - 10.1016/S1734-1140(12)70908-8 ER -
@article{ author = "Divljaković, Jovana and Milić, Marija and Timić, Tamara and Savić, Miroslav", year = "2012", abstract = "Background: Behavioral effects of benzodiazepines following repeated exposure vary according to the intrinsic efficacy of the benzodiazepine studied, treatment schedule and the behavioral parameters evaluated. Methods: We applied the behavioral paradigms of spontaneous locomotor activity, elevated plus maze and grip strength to investigate the sedative, anxiolyfic and myorelaxant effect of acute challenge with 2 mg/kg diazepam administered after 14 days of protracted treatment with 0.5, 2 or 10 mg/kg of diazepam. In addition, we studied the effects of everyday handling and intraperitoneal (ip) administration on animal behavior. Results: Tolerance to the sedative effect of 2 mg/kg diszepam ensued after 14 days of protracted treatment with 2 and 10 mg/kg of diazepam. In contrast, treatment with the lowest dose (0.5 mg/kg) of diazepam resulted in potentiation of the sedative effect of acute challenge with 2 mg/kg diazepam thus confounding the detection of the anxiolytic effect of diazepam. A sensitization-like response to the anxiolytic action of 2 mg/kg diazepam was seen after protracted treatment with the intermediate dose (2 mg/kg); however, anxiolytic effect was absent after protracted administration of the highest dose. Partial tolerance to the muscle relaxant effect of 2 mg/kg diazepam ensued after protracted treatment with diazepam regardless of the dose. Daily handling or ip administration did not alter the behavioral response to acute challenge with 2 mg/kg diazepam in all the three behavioral paradigms studied. Conclusion: The presented results showed that behavioral effects of acute challenge with diazepam were differently affected by the dose administered during protracted treatment.", publisher = "Polish Acad Sciences Inst Pharmacology, Krakow", journal = "Pharmacological Reports", title = "Tolerance liability of diazepam is dependent on the dose used for protracted treatment", volume = "64", number = "5", pages = "1116-1125", doi = "10.1016/S1734-1140(12)70908-8" }
Divljaković, J., Milić, M., Timić, T.,& Savić, M.. (2012). Tolerance liability of diazepam is dependent on the dose used for protracted treatment. in Pharmacological Reports Polish Acad Sciences Inst Pharmacology, Krakow., 64(5), 1116-1125. https://doi.org/10.1016/S1734-1140(12)70908-8
Divljaković J, Milić M, Timić T, Savić M. Tolerance liability of diazepam is dependent on the dose used for protracted treatment. in Pharmacological Reports. 2012;64(5):1116-1125. doi:10.1016/S1734-1140(12)70908-8 .
Divljaković, Jovana, Milić, Marija, Timić, Tamara, Savić, Miroslav, "Tolerance liability of diazepam is dependent on the dose used for protracted treatment" in Pharmacological Reports, 64, no. 5 (2012):1116-1125, https://doi.org/10.1016/S1734-1140(12)70908-8 . .