Приказ основних података о документу
Tolerance liability of diazepam is dependent on the dose used for protracted treatment
dc.creator | Divljaković, Jovana | |
dc.creator | Milić, Marija | |
dc.creator | Timić, Tamara | |
dc.creator | Savić, Miroslav | |
dc.date.accessioned | 2019-09-02T11:28:11Z | |
dc.date.available | 2019-09-02T11:28:11Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1734-1140 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1668 | |
dc.description.abstract | Background: Behavioral effects of benzodiazepines following repeated exposure vary according to the intrinsic efficacy of the benzodiazepine studied, treatment schedule and the behavioral parameters evaluated. Methods: We applied the behavioral paradigms of spontaneous locomotor activity, elevated plus maze and grip strength to investigate the sedative, anxiolyfic and myorelaxant effect of acute challenge with 2 mg/kg diazepam administered after 14 days of protracted treatment with 0.5, 2 or 10 mg/kg of diazepam. In addition, we studied the effects of everyday handling and intraperitoneal (ip) administration on animal behavior. Results: Tolerance to the sedative effect of 2 mg/kg diszepam ensued after 14 days of protracted treatment with 2 and 10 mg/kg of diazepam. In contrast, treatment with the lowest dose (0.5 mg/kg) of diazepam resulted in potentiation of the sedative effect of acute challenge with 2 mg/kg diazepam thus confounding the detection of the anxiolytic effect of diazepam. A sensitization-like response to the anxiolytic action of 2 mg/kg diazepam was seen after protracted treatment with the intermediate dose (2 mg/kg); however, anxiolytic effect was absent after protracted administration of the highest dose. Partial tolerance to the muscle relaxant effect of 2 mg/kg diazepam ensued after protracted treatment with diazepam regardless of the dose. Daily handling or ip administration did not alter the behavioral response to acute challenge with 2 mg/kg diazepam in all the three behavioral paradigms studied. Conclusion: The presented results showed that behavioral effects of acute challenge with diazepam were differently affected by the dose administered during protracted treatment. | en |
dc.publisher | Polish Acad Sciences Inst Pharmacology, Krakow | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175076/RS// | |
dc.rights | restrictedAccess | |
dc.source | Pharmacological Reports | |
dc.subject | spontaneous locomotor activity | en |
dc.subject | elevated plus maze | en |
dc.subject | grip strength | en |
dc.subject | tolerance | en |
dc.title | Tolerance liability of diazepam is dependent on the dose used for protracted treatment | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Савић, Мирослав; Дивљаковић, Јована; Милић, Марија; Тимић, Тамара; | |
dc.citation.volume | 64 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1116 | |
dc.citation.epage | 1125 | |
dc.citation.other | 64(5): 1116-1125 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000208844100010 | |
dc.identifier.doi | 10.1016/S1734-1140(12)70908-8 | |
dc.identifier.pmid | 23238468 | |
dc.identifier.scopus | 2-s2.0-84873737172 | |
dc.type.version | publishedVersion |