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High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations

Нема приказа
Аутори
Vladimirov, S
Marković, L
Agbaba, Danica
Živanov-Stakić, Dobrila
Brborić, Jasmina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
A specific and simple HPLC procedure was developed, su table for the determination of dindamycin hydrochloride monohydrate (CLHC) and clindamycin 2-dihydrogenphosphate (CLPH) in pharmaceutical formulations. Rp-HPLC analysis was performed with a LCD-Analytical Consta Metric 3000 system, equipped with a Spectro Monitor 3100 UV/VIS detector. Lincosamides assay procedures were carried out on a Supelcosil R LC-18-DB (250 × 4,6 mm, 5 μm particles) column in an acetonitrile-potassium dihydrogenphosphate buffer (0.1 M; pH 2.50) (225:775 v/v) as mobile phase. Column effluents were monitored at 206 nm for clindamycin. The calibration curves in concentration ranges from 200 to 1800 μg/ml were established for the investigated clindamycins. The HPLC method was applied for the determination of clindamycin in pharmaceutical formulations. The obtained results and statistical parameters for both the investigated clindamycins in pharmaceutical formulations, were satisfactory and ranged from 99.99% to 10...4.18% (R.S.D. was ranged from 0.79% to 0.99%).

Кључне речи:
Clindamycin / HPLC determination / Pharmaceutical formulations
Извор:
Journal of the Serbian Chemical Society, 1997, 62, 2, 177-181
Издавач:
  • Srpsko hemijsko društvo, Beograd

ISSN: 0352-5139

Scopus: 2-s2.0-0031522045
[ Google Scholar ]
2
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/166
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy
TY  - JOUR
AU  - Vladimirov, S
AU  - Marković, L
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
AU  - Brborić, Jasmina
PY  - 1997
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/166
AB  - A specific and simple HPLC procedure was developed, su table for the determination of dindamycin hydrochloride monohydrate (CLHC) and clindamycin 2-dihydrogenphosphate (CLPH) in pharmaceutical formulations. Rp-HPLC analysis was performed with a LCD-Analytical Consta Metric 3000 system, equipped with a Spectro Monitor 3100 UV/VIS detector. Lincosamides assay procedures were carried out on a Supelcosil R LC-18-DB (250 × 4,6 mm, 5 μm particles) column in an acetonitrile-potassium dihydrogenphosphate buffer (0.1 M; pH 2.50) (225:775 v/v) as mobile phase. Column effluents were monitored at 206 nm for clindamycin. The calibration curves in concentration ranges from 200 to 1800 μg/ml were established for the investigated clindamycins. The HPLC method was applied for the determination of clindamycin in pharmaceutical formulations. The obtained results and statistical parameters for both the investigated clindamycins in pharmaceutical formulations, were satisfactory and ranged from 99.99% to 104.18% (R.S.D. was ranged from 0.79% to 0.99%).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations
VL  - 62
IS  - 2
SP  - 177
EP  - 181
ER  - 
@article{
author = "Vladimirov, S and Marković, L and Agbaba, Danica and Živanov-Stakić, Dobrila and Brborić, Jasmina",
year = "1997",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/166",
abstract = "A specific and simple HPLC procedure was developed, su table for the determination of dindamycin hydrochloride monohydrate (CLHC) and clindamycin 2-dihydrogenphosphate (CLPH) in pharmaceutical formulations. Rp-HPLC analysis was performed with a LCD-Analytical Consta Metric 3000 system, equipped with a Spectro Monitor 3100 UV/VIS detector. Lincosamides assay procedures were carried out on a Supelcosil R LC-18-DB (250 × 4,6 mm, 5 μm particles) column in an acetonitrile-potassium dihydrogenphosphate buffer (0.1 M; pH 2.50) (225:775 v/v) as mobile phase. Column effluents were monitored at 206 nm for clindamycin. The calibration curves in concentration ranges from 200 to 1800 μg/ml were established for the investigated clindamycins. The HPLC method was applied for the determination of clindamycin in pharmaceutical formulations. The obtained results and statistical parameters for both the investigated clindamycins in pharmaceutical formulations, were satisfactory and ranged from 99.99% to 104.18% (R.S.D. was ranged from 0.79% to 0.99%).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations",
volume = "62",
number = "2",
pages = "177-181"
}
Vladimirov S, Marković L, Agbaba D, Živanov-Stakić D, Brborić J. High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations. Journal of the Serbian Chemical Society. 1997;62(2):177-181
Vladimirov, S., Marković, L., Agbaba, D., Živanov-Stakić, D.,& Brborić, J. (1997). High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations.
Journal of the Serbian Chemical SocietySrpsko hemijsko društvo, Beograd., 62(2), 177-181.
Vladimirov S, Marković L, Agbaba Danica, Živanov-Stakić Dobrila, Brborić Jasmina, "High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations" 62, no. 2 (1997):177-181

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