Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria

2012
Authors
Poluga, JasminaDopsaj, Violeta

Veljković, Milena
Maksić, N.
Stojaković, Sonja
Dunjić, Radica
Dakić, Zorica
Pavlović, Milorad
Article (Published version)
Metadata
Show full item recordAbstract
In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactate...s.
Keywords:
Malaria / cytokines / TNF-alpha / IL-6 / parasitemiaSource:
Archives of Biological Sciences, 2012, 64, 4, 1577-1583Publisher:
- Srpsko biološko društvo, Beograd, i dr.
DOI: 10.2298/ABS1204577P
ISSN: 0354-4664
WoS: 000312046200041
Scopus: 2-s2.0-84867833149
Collections
Institution/Community
PharmacyTY - JOUR AU - Poluga, Jasmina AU - Dopsaj, Violeta AU - Veljković, Milena AU - Maksić, N. AU - Stojaković, Sonja AU - Dunjić, Radica AU - Dakić, Zorica AU - Pavlović, Milorad PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1682 AB - In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria VL - 64 IS - 4 SP - 1577 EP - 1583 DO - 10.2298/ABS1204577P ER -
@article{ author = "Poluga, Jasmina and Dopsaj, Violeta and Veljković, Milena and Maksić, N. and Stojaković, Sonja and Dunjić, Radica and Dakić, Zorica and Pavlović, Milorad", year = "2012", abstract = "In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria", volume = "64", number = "4", pages = "1577-1583", doi = "10.2298/ABS1204577P" }
Poluga, J., Dopsaj, V., Veljković, M., Maksić, N., Stojaković, S., Dunjić, R., Dakić, Z.,& Pavlović, M.. (2012). Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 64(4), 1577-1583. https://doi.org/10.2298/ABS1204577P
Poluga J, Dopsaj V, Veljković M, Maksić N, Stojaković S, Dunjić R, Dakić Z, Pavlović M. Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria. in Archives of Biological Sciences. 2012;64(4):1577-1583. doi:10.2298/ABS1204577P .
Poluga, Jasmina, Dopsaj, Violeta, Veljković, Milena, Maksić, N., Stojaković, Sonja, Dunjić, Radica, Dakić, Zorica, Pavlović, Milorad, "Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria" in Archives of Biological Sciences, 64, no. 4 (2012):1577-1583, https://doi.org/10.2298/ABS1204577P . .