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Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria

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2012
1680.pdf (534.8Kb)
Authors
Poluga, Jasmina
Dopsaj, Violeta
Veljković, Milena
Maksić, N.
Stojaković, Sonja
Dunjić, Radica
Dakić, Zorica
Pavlović, Milorad
Article (Published version)
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Abstract
In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactate...s.

Keywords:
Malaria / cytokines / TNF-alpha / IL-6 / parasitemia
Source:
Archives of Biological Sciences, 2012, 64, 4, 1577-1583
Publisher:
  • Srpsko biološko društvo, Beograd, i dr.

DOI: 10.2298/ABS1204577P

ISSN: 0354-4664

WoS: 000312046200041

Scopus: 2-s2.0-84867833149
[ Google Scholar ]
1
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1682
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Poluga, Jasmina
AU  - Dopsaj, Violeta
AU  - Veljković, Milena
AU  - Maksić, N.
AU  - Stojaković, Sonja
AU  - Dunjić, Radica
AU  - Dakić, Zorica
AU  - Pavlović, Milorad
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1682
AB  - In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria
VL  - 64
IS  - 4
SP  - 1577
EP  - 1583
DO  - 10.2298/ABS1204577P
ER  - 
@article{
author = "Poluga, Jasmina and Dopsaj, Violeta and Veljković, Milena and Maksić, N. and Stojaković, Sonja and Dunjić, Radica and Dakić, Zorica and Pavlović, Milorad",
year = "2012",
abstract = "In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria",
volume = "64",
number = "4",
pages = "1577-1583",
doi = "10.2298/ABS1204577P"
}
Poluga, J., Dopsaj, V., Veljković, M., Maksić, N., Stojaković, S., Dunjić, R., Dakić, Z.,& Pavlović, M.. (2012). Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 64(4), 1577-1583.
https://doi.org/10.2298/ABS1204577P
Poluga J, Dopsaj V, Veljković M, Maksić N, Stojaković S, Dunjić R, Dakić Z, Pavlović M. Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria. in Archives of Biological Sciences. 2012;64(4):1577-1583.
doi:10.2298/ABS1204577P .
Poluga, Jasmina, Dopsaj, Violeta, Veljković, Milena, Maksić, N., Stojaković, Sonja, Dunjić, Radica, Dakić, Zorica, Pavlović, Milorad, "Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria" in Archives of Biological Sciences, 64, no. 4 (2012):1577-1583,
https://doi.org/10.2298/ABS1204577P . .

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