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Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported Malaria

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2012
1680.pdf (534.8Kb)
Authors
Poluga, Jasmina
Dopsaj, Violeta
Veljković, Milena
Maksić, N.
Stojaković, Sonja
Dunjić, Radica
Dakić, Zorica
Pavlović, Milorad
Article (Published version)
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Abstract
In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-alpha and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-alpha and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-alpha and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-alpha values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenase, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactate...s.

Keywords:
Malaria / cytokines / TNF-alpha / IL-6 / parasitemia
Source:
Archives of Biological Sciences, 2012, 64, 4, 1577-1583
Publisher:
  • Srpsko biološko društvo, Beograd, i dr.

DOI: 10.2298/ABS1204577P

ISSN: 0354-4664

WoS: 000312046200041

Scopus: 2-s2.0-84867833149
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1682
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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