Приказ основних података о документу

dc.creatorPilipović, Ivan
dc.creatorRadojević, Katarina
dc.creatorPerišić, Milica
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:28:34Z
dc.date.available2019-09-02T11:28:34Z
dc.date.issued2012
dc.identifier.issn0077-8923
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1686
dc.description.abstractThis paper highlights the multiple putative thymic and extrathymic points of intersection and interaction between glucocorticoids (GCs) and catecholamines (CAs)-the end-point mediators of the major routes of communication between the brain and the immune system-in the context of intricate thymic T cell-developmental tuning. More specifically, we discuss in detail findings indicating that adrenal GCs can influence thymopoiesis by adjusting directly and/or indirectly (through modulation of pituitary and local ACTH synthesis) not only thymic GC synthesis, in a cell type-specific manner, but also thymic CA bioavailability (via altering CA outflow from sympathetic nerve endings and local CA synthesis), beta and alpha(1)-adrenoceptor (AR) expression, and/or AR-mediated intracellular signal transduction in thymic cells. In addition, this short review points to GC-and CA-sensitive stages along the multistep T cell-developmental journey and the possible effects of altered GC, and consequently CA signaling, on thymopoietic efficiency.en
dc.publisherBlackwell Science Publ, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroimmunomodulation in Health and Disease I
dc.subjectglucocorticoidsen
dc.subjectcatecholaminesen
dc.subjectbeta-adrenergic receptorsen
dc.subjectrat thymusen
dc.subjectT cell developmenten
dc.titleGlucocorticoid-catecholamine interplay within the composite thymopoietic regulatory networken
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадојевић, Катарина; Пилиповић, Иван; Лепосавић, Гордана; Перишић, Милица;
dc.citation.volume1261
dc.citation.spage34
dc.citation.epage41
dc.citation.other1261: 34-41
dc.citation.rankM21
dc.identifier.wos000312537900006
dc.identifier.doi10.1111/j.1749-6632.2012.06623.x
dc.identifier.pmid22823391
dc.identifier.scopus2-s2.0-84864081722
dc.type.versionpublishedVersion


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Приказ основних података о документу