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Pharmacophore Development and SAR Studies of Imidazoline Receptor Ligands
dc.creator | Nikolić, Katarina | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:28:41Z | |
dc.date.available | 2019-09-02T11:28:41Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1389-5575 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1691 | |
dc.description.abstract | Relationship between biological responses and binding affinities at I-1/I-2/I-3 imidazoline receptors of compounds with imidazoline, pyrroline or oxazoline moieties was studied by 2D-QSAR, 3D-QSAR and quantitative pharmacophore development approaches. Since the I-1 imidazoline receptor is involved in central inhibition of sympathicus that produce hypotensive effect, the I-2 receptor is allosteric modulator of monoamine oxidase B (MAO-B) and the I-3 receptor regulates insulin secretion from pancreatic beta-cells, design and synthesis of selective I-1/I-2/I-3 imidazoline ligands are very important for the development of new effective therapeutic agents. New agonists and antagonists with high selectivity for I-1/I-2/I-3 imidazoline receptor classes have been recently synthesized and examined. The present review will highlight the main chemical diversity and pharmacophore features of selective I-1/I-2/I-3 imidazoline receptor ligands. | en |
dc.publisher | Bentham Science Publ Ltd, Sharjah | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS// | |
dc.rights | restrictedAccess | |
dc.source | Mini-Reviews in Medicinal Chemistry | |
dc.subject | I1-imidazoline receptors | en |
dc.subject | I2-imidazoline receptors | en |
dc.subject | I3-imidazoline receptors | en |
dc.title | Pharmacophore Development and SAR Studies of Imidazoline Receptor Ligands | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aгбаба, Даница; Николић, Катарина; | |
dc.citation.volume | 12 | |
dc.citation.issue | 14 | |
dc.citation.spage | 1542 | |
dc.citation.epage | 1555 | |
dc.citation.other | 12(14): 1542-1555 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000311955300010 | |
dc.identifier.doi | 10.2174/138955712803832636 | |
dc.identifier.pmid | 22512575 | |
dc.identifier.scopus | 2-s2.0-84873156974 | |
dc.type.version | publishedVersion |