Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis
Samo za registrovane korisnike
2012
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually diergic changes in thymopoietic efficiency, which in rodents occur around puberty and lead to a substantial phenotypic and functional remodeling of the peripheral T-cell compartment. This in turn leads to an alteration in the susceptibility to infection and various immunologically mediated pathologies. Our laboratory has explored interdependence in the programming and development of the hypothalamo-pituitary-gonadal axis and thymus using experimental model of neonatal androgenization. We have outlined critical points in the complex process of T-cell development depending on neonatal androgen imprinting and the peripheral outcome of these changes and have pointed to underlying mechanisms. Our research has particularly contributed to an understanding of the putative role of changes in catecholamine-mediated communications in the thymopoietic alterations in adult neonat...ally androgenized rats.
Ključne reči:
Thymus development / Immunological sexual diergism / Thymopoiesis / Gonadal hormones / Catecholamines / beta-Adrenergic receptors / Neonatal androgenizationIzvor:
Immunologic Research, 2012, 52, 1-2, 7-19Izdavač:
- Humana Press Inc, Totowa
Finansiranje / projekti:
- Neuroendokrina modulacija imunskog odgovora: uloga simpato-adrenomedularnog sistema (RS-MESTD-MPN2006-2010-145049)
DOI: 10.1007/s12026-012-8278-6
ISSN: 0257-277X
PubMed: 22407539
WoS: 000303057600003
Scopus: 2-s2.0-84859910349
Institucija/grupa
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Perišić, Milica AU - Pilipović, Ivan PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1693 AB - There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually diergic changes in thymopoietic efficiency, which in rodents occur around puberty and lead to a substantial phenotypic and functional remodeling of the peripheral T-cell compartment. This in turn leads to an alteration in the susceptibility to infection and various immunologically mediated pathologies. Our laboratory has explored interdependence in the programming and development of the hypothalamo-pituitary-gonadal axis and thymus using experimental model of neonatal androgenization. We have outlined critical points in the complex process of T-cell development depending on neonatal androgen imprinting and the peripheral outcome of these changes and have pointed to underlying mechanisms. Our research has particularly contributed to an understanding of the putative role of changes in catecholamine-mediated communications in the thymopoietic alterations in adult neonatally androgenized rats. PB - Humana Press Inc, Totowa T2 - Immunologic Research T1 - Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis VL - 52 IS - 1-2 SP - 7 EP - 19 DO - 10.1007/s12026-012-8278-6 ER -
@article{ author = "Leposavić, Gordana and Perišić, Milica and Pilipović, Ivan", year = "2012", abstract = "There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually diergic changes in thymopoietic efficiency, which in rodents occur around puberty and lead to a substantial phenotypic and functional remodeling of the peripheral T-cell compartment. This in turn leads to an alteration in the susceptibility to infection and various immunologically mediated pathologies. Our laboratory has explored interdependence in the programming and development of the hypothalamo-pituitary-gonadal axis and thymus using experimental model of neonatal androgenization. We have outlined critical points in the complex process of T-cell development depending on neonatal androgen imprinting and the peripheral outcome of these changes and have pointed to underlying mechanisms. Our research has particularly contributed to an understanding of the putative role of changes in catecholamine-mediated communications in the thymopoietic alterations in adult neonatally androgenized rats.", publisher = "Humana Press Inc, Totowa", journal = "Immunologic Research", title = "Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis", volume = "52", number = "1-2", pages = "7-19", doi = "10.1007/s12026-012-8278-6" }
Leposavić, G., Perišić, M.,& Pilipović, I.. (2012). Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis. in Immunologic Research Humana Press Inc, Totowa., 52(1-2), 7-19. https://doi.org/10.1007/s12026-012-8278-6
Leposavić G, Perišić M, Pilipović I. Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis. in Immunologic Research. 2012;52(1-2):7-19. doi:10.1007/s12026-012-8278-6 .
Leposavić, Gordana, Perišić, Milica, Pilipović, Ivan, "Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis" in Immunologic Research, 52, no. 1-2 (2012):7-19, https://doi.org/10.1007/s12026-012-8278-6 . .