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dc.creatorLeposavić, Gordana
dc.creatorPerišić, Milica
dc.creatorPilipović, Ivan
dc.date.accessioned2019-09-02T11:28:46Z
dc.date.available2019-09-02T11:28:46Z
dc.date.issued2012
dc.identifier.issn0257-277X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1693
dc.description.abstractThere is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually diergic changes in thymopoietic efficiency, which in rodents occur around puberty and lead to a substantial phenotypic and functional remodeling of the peripheral T-cell compartment. This in turn leads to an alteration in the susceptibility to infection and various immunologically mediated pathologies. Our laboratory has explored interdependence in the programming and development of the hypothalamo-pituitary-gonadal axis and thymus using experimental model of neonatal androgenization. We have outlined critical points in the complex process of T-cell development depending on neonatal androgen imprinting and the peripheral outcome of these changes and have pointed to underlying mechanisms. Our research has particularly contributed to an understanding of the putative role of changes in catecholamine-mediated communications in the thymopoietic alterations in adult neonatally androgenized rats.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsrestrictedAccess
dc.sourceImmunologic Research
dc.subjectThymus developmenten
dc.subjectImmunological sexual diergismen
dc.subjectThymopoiesisen
dc.subjectGonadal hormonesen
dc.subjectCatecholaminesen
dc.subjectbeta-Adrenergic receptorsen
dc.subjectNeonatal androgenizationen
dc.titleRole of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛепосавић, Гордана; Пилиповић, Иван; Перишић, Милица;
dc.citation.volume52
dc.citation.issue1-2
dc.citation.spage7
dc.citation.epage19
dc.citation.other52(1-2): 7-19
dc.citation.rankM22
dc.identifier.wos000303057600003
dc.identifier.doi10.1007/s12026-012-8278-6
dc.identifier.pmid22407539
dc.identifier.scopus2-s2.0-84859910349
dc.identifier.rcubconv_2624
dc.type.versionpublishedVersion


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