Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy
Само за регистроване кориснике
2012
Аутори
Stefanović, AleksandraArdalić, Daniela
Kotur-Stevuljević, Jelena
Vujović, Ana
Spasić, Slavica
Spasojević-Kalimanovska, Vesna
Jelić-Ivanović, Zorana
Mandić-Marković, Vesna
Miković, Željko
Cerović, Nikola
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon) activity method. As a parameter of oxidative stress status we measured the redox balance. Paraoxonase-1 activity significantly decreased at gestational week 32. In addition, the lipid profile was more atherogenic. Redox balance was significantly increased across gestational weeks. There were independent direct associations between maternal smoking habits before pregnancy, glucose concentrations and redox balance with PON1 activity in the third trimester. This study shows that pregnancy is followed by a decrease in PON1 activity and increased risk for development of cardiovascular diseases. We conclude that changes in paraoxonase-1 status duri...ng pregnancy are associated with maternal oxidative stress status and smoking habits.
Кључне речи:
Pregnancy / Paraoxonase-1 / Oxidative stress / Cardiovascular disease / PhenotypeИзвор:
Research in Microbiology, 2012, 33, 1, 20-26Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
DOI: 10.1016/j.reprotox.2011.10.009
ISSN: 0890-6238
PubMed: 22074696
WoS: 000300762700003
Scopus: 2-s2.0-84856739790
Институција/група
PharmacyTY - JOUR AU - Stefanović, Aleksandra AU - Ardalić, Daniela AU - Kotur-Stevuljević, Jelena AU - Vujović, Ana AU - Spasić, Slavica AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana AU - Mandić-Marković, Vesna AU - Miković, Željko AU - Cerović, Nikola PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1694 AB - The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon) activity method. As a parameter of oxidative stress status we measured the redox balance. Paraoxonase-1 activity significantly decreased at gestational week 32. In addition, the lipid profile was more atherogenic. Redox balance was significantly increased across gestational weeks. There were independent direct associations between maternal smoking habits before pregnancy, glucose concentrations and redox balance with PON1 activity in the third trimester. This study shows that pregnancy is followed by a decrease in PON1 activity and increased risk for development of cardiovascular diseases. We conclude that changes in paraoxonase-1 status during pregnancy are associated with maternal oxidative stress status and smoking habits. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Research in Microbiology T1 - Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy VL - 33 IS - 1 SP - 20 EP - 26 DO - 10.1016/j.reprotox.2011.10.009 ER -
@article{ author = "Stefanović, Aleksandra and Ardalić, Daniela and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola", year = "2012", abstract = "The purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon) activity method. As a parameter of oxidative stress status we measured the redox balance. Paraoxonase-1 activity significantly decreased at gestational week 32. In addition, the lipid profile was more atherogenic. Redox balance was significantly increased across gestational weeks. There were independent direct associations between maternal smoking habits before pregnancy, glucose concentrations and redox balance with PON1 activity in the third trimester. This study shows that pregnancy is followed by a decrease in PON1 activity and increased risk for development of cardiovascular diseases. We conclude that changes in paraoxonase-1 status during pregnancy are associated with maternal oxidative stress status and smoking habits.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Research in Microbiology", title = "Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy", volume = "33", number = "1", pages = "20-26", doi = "10.1016/j.reprotox.2011.10.009" }
Stefanović, A., Ardalić, D., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2012). Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy. in Research in Microbiology Pergamon-Elsevier Science Ltd, Oxford., 33(1), 20-26. https://doi.org/10.1016/j.reprotox.2011.10.009
Stefanović A, Ardalić D, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy. in Research in Microbiology. 2012;33(1):20-26. doi:10.1016/j.reprotox.2011.10.009 .
Stefanović, Aleksandra, Ardalić, Daniela, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Longitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancy" in Research in Microbiology, 33, no. 1 (2012):20-26, https://doi.org/10.1016/j.reprotox.2011.10.009 . .