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dc.creatorStefanović, Aleksandra
dc.creatorArdalić, Daniela
dc.creatorKotur-Stevuljević, Jelena
dc.creatorVujović, Ana
dc.creatorSpasić, Slavica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.creatorMandić-Marković, Vesna
dc.creatorMiković, Željko
dc.creatorCerović, Nikola
dc.date.accessioned2019-09-02T11:28:47Z
dc.date.available2019-09-02T11:28:47Z
dc.date.issued2012
dc.identifier.issn0890-6238
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1694
dc.description.abstractThe purpose of the present study was to determine changes in plasma paraoxonase-1 activity (an indicator of paraoxonase phenotype) throughout normal pregnancy and its relationship with maternal oxidative stress status. The frequencies of the paraoxonase-1 phenotype in the studied population were determined using a two-substrate (paraoxon/diazoxon) activity method. As a parameter of oxidative stress status we measured the redox balance. Paraoxonase-1 activity significantly decreased at gestational week 32. In addition, the lipid profile was more atherogenic. Redox balance was significantly increased across gestational weeks. There were independent direct associations between maternal smoking habits before pregnancy, glucose concentrations and redox balance with PON1 activity in the third trimester. This study shows that pregnancy is followed by a decrease in PON1 activity and increased risk for development of cardiovascular diseases. We conclude that changes in paraoxonase-1 status during pregnancy are associated with maternal oxidative stress status and smoking habits.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceResearch in Microbiology
dc.subjectPregnancyen
dc.subjectParaoxonase-1en
dc.subjectOxidative stressen
dc.subjectCardiovascular diseaseen
dc.subjectPhenotypeen
dc.titleLongitudinal changes in PON1 activities, PON1 phenotype distribution and oxidative status throughout normal pregnancyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрдалић, Даниела; Вујовић, Aна; Мандић-Марковић, Весна; Миковић, Жељко; Спасојевић-Калимановска, Весна; Церовић, Никола; Спасић, Славица; Стефановић, Aлександра; Котур-Стевуљевић, Јелена; Јелић-Ивановић, Зорана;
dc.citation.volume33
dc.citation.issue1
dc.citation.spage20
dc.citation.epage26
dc.citation.other33(1): 20-26
dc.citation.rankM22
dc.identifier.wos000300762700003
dc.identifier.doi10.1016/j.reprotox.2011.10.009
dc.identifier.pmid22074696
dc.identifier.scopus2-s2.0-84856739790
dc.identifier.rcubconv_2597
dc.type.versionpublishedVersion


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