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dc.creatorMašić, Ivana
dc.creatorIlić, Ilija
dc.creatorDreu, Rok
dc.creatorIbrić, Svetlana
dc.creatorParojčić, Jelena
dc.creatorĐurić, Zorica
dc.date.accessioned2019-09-02T11:28:50Z
dc.date.available2019-09-02T11:28:50Z
dc.date.issued2012
dc.identifier.issn0378-5173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1697
dc.description.abstractThe aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and good flow properties. The results obtained indicate that conventional fluid bed granulator may be suitable for production of highly spherical agglomerates, particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absence of interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectMelt agglomerationen
dc.subjectFluid beden
dc.subjectIn situ melt granulationen
dc.subjectGranule shapeen
dc.subjectBinder particle sizeen
dc.titleAn investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПаројчић, Јелена; Машић, Ивана; Дреу, Рок; Ђурић, Зорица; Ибрић, Светлана; Илић, Илија;
dc.citation.volume423
dc.citation.issue2
dc.citation.spage202
dc.citation.epage212
dc.citation.other423(2): 202-212
dc.citation.rankM21
dc.identifier.wos000301157000007
dc.identifier.doi10.1016/j.ijpharm.2011.12.013
dc.identifier.pmid22197773
dc.identifier.scopus2-s2.0-84856547104
dc.identifier.rcubconv_2602
dc.type.versionpublishedVersion


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