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dc.creatorStanković, Sanja
dc.creatorAšanin, Milika
dc.creatorMajkić-Singh, Nada
dc.creatorIgnjatović, Svetlana
dc.creatorMihailović, Mirjana
dc.creatorNikolajević, Ivica
dc.creatorMrdović, Igor
dc.creatorMatić, Dragan
dc.creatorSavić, Lidija
dc.creatorMarinković, Jelena
dc.creatorOstojić, Miodrag
dc.creatorVasiljević, Zorana
dc.date.accessioned2019-09-02T11:28:56Z
dc.date.available2019-09-02T11:28:56Z
dc.date.issued2012
dc.identifier.issn1433-6510
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1701
dc.description.abstractBackground: The predictive value of myeloperoxidase (MPO) in ST-segment elevation myocardial infarction (STEM I) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of the present study was to investigate MPO as a predictor of in-hospital mortality in STEMI patients treated by primary PCI. Methods: Study population consisted of 189 STEMI patients having undergone primary PCI. Plasma MPO level was measured 24 hours after symptom onset using chemiluminescent microparticle immunoassay (Abbott Diagnostics, Germany). The Receiver Operating Characteristic analysis was performed to identify the most useful MPO cut-off level for the prediction of in-hospital mortality. The patients were divided into two groups according to the cut-off MPO level: high MPO group (>= 840 pmol/L, n = 65) and low M PO group ( lt 840 pmol/L, n = 124). Results: The high M PO group had significantly more frequent anterior wall infarctions (p lt 0.001) and Killip class >1 on admission (p=0.013) as well as lower left ventricular ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP) (p=0.029) than the low MPO group. The incidence of in-hospital mortality was 5.8% and was significantly higher in the high M PO group (13.8%) than in the low MPO group (1.6%) (p=0.001). Multiple logistic regression analysis identified the plasma MPO level as an independent predictor of in-hospital mortality (OR 3.88, 95%CI 1.13 - 13.34, p=0.031). Conclusions: Plasma M PO level independently predicts in-hospital mortality in STEMI patients treated by primary PCI. (Clin. Lab. 2012;58:125-131)en
dc.publisherClin Lab Publ, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Laboratory
dc.subjectMyeloperoxidaseen
dc.subjectacute myocardial infarctionen
dc.subjectSTEMI, in-hospital mortalityen
dc.subjectprimary percutaneous coronary interventionen
dc.titleThe Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Interventionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаринковић, Јелена; Михаиловић, Мирјана; Aшанин, Милика; Мајкић-Сингх, Нада; Мрдовић, Игор; Игњатовић, Светлана; Матић, Драган; Савић, Лидија; Остојић, Миодраг; Станковић, Сања; Васиљевић, Зорана; Николајевић, Ивица;
dc.citation.volume58
dc.citation.issue1-2
dc.citation.spage125
dc.citation.epage131
dc.citation.other58(1-2): 125-131
dc.citation.rankM23
dc.identifier.wos000300339200016
dc.identifier.pmid22372355
dc.identifier.rcubconv_2592
dc.type.versionpublishedVersion


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