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The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention
dc.creator | Stanković, Sanja | |
dc.creator | Ašanin, Milika | |
dc.creator | Majkić-Singh, Nada | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Nikolajević, Ivica | |
dc.creator | Mrdović, Igor | |
dc.creator | Matić, Dragan | |
dc.creator | Savić, Lidija | |
dc.creator | Marinković, Jelena | |
dc.creator | Ostojić, Miodrag | |
dc.creator | Vasiljević, Zorana | |
dc.date.accessioned | 2019-09-02T11:28:56Z | |
dc.date.available | 2019-09-02T11:28:56Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1433-6510 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1701 | |
dc.description.abstract | Background: The predictive value of myeloperoxidase (MPO) in ST-segment elevation myocardial infarction (STEM I) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of the present study was to investigate MPO as a predictor of in-hospital mortality in STEMI patients treated by primary PCI. Methods: Study population consisted of 189 STEMI patients having undergone primary PCI. Plasma MPO level was measured 24 hours after symptom onset using chemiluminescent microparticle immunoassay (Abbott Diagnostics, Germany). The Receiver Operating Characteristic analysis was performed to identify the most useful MPO cut-off level for the prediction of in-hospital mortality. The patients were divided into two groups according to the cut-off MPO level: high MPO group (>= 840 pmol/L, n = 65) and low M PO group ( lt 840 pmol/L, n = 124). Results: The high M PO group had significantly more frequent anterior wall infarctions (p lt 0.001) and Killip class >1 on admission (p=0.013) as well as lower left ventricular ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP) (p=0.029) than the low MPO group. The incidence of in-hospital mortality was 5.8% and was significantly higher in the high M PO group (13.8%) than in the low MPO group (1.6%) (p=0.001). Multiple logistic regression analysis identified the plasma MPO level as an independent predictor of in-hospital mortality (OR 3.88, 95%CI 1.13 - 13.34, p=0.031). Conclusions: Plasma M PO level independently predicts in-hospital mortality in STEMI patients treated by primary PCI. (Clin. Lab. 2012;58:125-131) | en |
dc.publisher | Clin Lab Publ, Heidelberg | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Laboratory | |
dc.subject | Myeloperoxidase | en |
dc.subject | acute myocardial infarction | en |
dc.subject | STEMI, in-hospital mortality | en |
dc.subject | primary percutaneous coronary intervention | en |
dc.title | The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Маринковић, Јелена; Михаиловић, Мирјана; Aшанин, Милика; Мајкић-Сингх, Нада; Мрдовић, Игор; Игњатовић, Светлана; Матић, Драган; Савић, Лидија; Остојић, Миодраг; Станковић, Сања; Васиљевић, Зорана; Николајевић, Ивица; | |
dc.citation.volume | 58 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 125 | |
dc.citation.epage | 131 | |
dc.citation.other | 58(1-2): 125-131 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000300339200016 | |
dc.identifier.pmid | 22372355 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1701 | |
dc.type.version | publishedVersion |
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