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Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study

Authorized Users Only
2012
Authors
Kundaković, Tatjana
Milenković, Marina
Zlatković, Sasa
Nikolić, Vesna D.
Nikolić, Goran
Binić, Ivana
Article (Published version)
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Abstract
Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without sig...nificant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.

Keywords:
Venous leg ulcers / Ointment / Allium sativum / Hypericum perforatum / Calendula officinalis
Source:
Forschende Komplementarmedizin, 2012, 19, 1, 26-30
Publisher:
  • Karger, Basel
Projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.1159/000335786

ISSN: 1021-7096

PubMed: 22398923

WoS: 000302383900005

Scopus: 2-s2.0-84858326479
[ Google Scholar ]
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7
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1706
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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