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Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study

Authorized Users Only
2012
Authors
Kundaković, Tatjana
Milenković, Marina
Zlatković, Sasa
Nikolić, Vesna D.
Nikolić, Goran
Binić, Ivana
Article (Published version)
Metadata
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Abstract
Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without sig...nificant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.

Keywords:
Venous leg ulcers / Ointment / Allium sativum / Hypericum perforatum / Calendula officinalis
Source:
Forschende Komplementarmedizin, 2012, 19, 1, 26-30
Publisher:
  • Karger, Basel
Funding / projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.1159/000335786

ISSN: 1021-7096

PubMed: 22398923

WoS: 000302383900005

Scopus: 2-s2.0-84858326479
[ Google Scholar ]
9
8
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1706
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Milenković, Marina
AU  - Zlatković, Sasa
AU  - Nikolić, Vesna D.
AU  - Nikolić, Goran
AU  - Binić, Ivana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1706
AB  - Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.
PB  - Karger, Basel
T2  - Forschende Komplementarmedizin
T1  - Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study
VL  - 19
IS  - 1
SP  - 26
EP  - 30
DO  - 10.1159/000335786
ER  - 
@article{
author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Nikolić, Vesna D. and Nikolić, Goran and Binić, Ivana",
year = "2012",
abstract = "Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.",
publisher = "Karger, Basel",
journal = "Forschende Komplementarmedizin",
title = "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study",
volume = "19",
number = "1",
pages = "26-30",
doi = "10.1159/000335786"
}
Kundaković, T., Milenković, M., Zlatković, S., Nikolić, V. D., Nikolić, G.,& Binić, I.. (2012). Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin
Karger, Basel., 19(1), 26-30.
https://doi.org/10.1159/000335786
Kundaković T, Milenković M, Zlatković S, Nikolić VD, Nikolić G, Binić I. Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin. 2012;19(1):26-30.
doi:10.1159/000335786 .
Kundaković, Tatjana, Milenković, Marina, Zlatković, Sasa, Nikolić, Vesna D., Nikolić, Goran, Binić, Ivana, "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study" in Forschende Komplementarmedizin, 19, no. 1 (2012):26-30,
https://doi.org/10.1159/000335786 . .

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