Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study
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2012
Authors
Kundaković, TatjanaMilenković, Marina
Zlatković, Sasa
Nikolić, Vesna D.
Nikolić, Goran
Binić, Ivana
Article (Published version)
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Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without sig...nificant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.
Keywords:
Venous leg ulcers / Ointment / Allium sativum / Hypericum perforatum / Calendula officinalisSource:
Forschende Komplementarmedizin, 2012, 19, 1, 26-30Publisher:
- Karger, Basel
Funding / projects:
DOI: 10.1159/000335786
ISSN: 1021-7096
PubMed: 22398923
WoS: 000302383900005
Scopus: 2-s2.0-84858326479
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Institution/Community
PharmacyTY - JOUR AU - Kundaković, Tatjana AU - Milenković, Marina AU - Zlatković, Sasa AU - Nikolić, Vesna D. AU - Nikolić, Goran AU - Binić, Ivana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1706 AB - Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties. PB - Karger, Basel T2 - Forschende Komplementarmedizin T1 - Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study VL - 19 IS - 1 SP - 26 EP - 30 DO - 10.1159/000335786 ER -
@article{ author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Nikolić, Vesna D. and Nikolić, Goran and Binić, Ivana", year = "2012", abstract = "Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.", publisher = "Karger, Basel", journal = "Forschende Komplementarmedizin", title = "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study", volume = "19", number = "1", pages = "26-30", doi = "10.1159/000335786" }
Kundaković, T., Milenković, M., Zlatković, S., Nikolić, V. D., Nikolić, G.,& Binić, I.. (2012). Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin Karger, Basel., 19(1), 26-30. https://doi.org/10.1159/000335786
Kundaković T, Milenković M, Zlatković S, Nikolić VD, Nikolić G, Binić I. Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study. in Forschende Komplementarmedizin. 2012;19(1):26-30. doi:10.1159/000335786 .
Kundaković, Tatjana, Milenković, Marina, Zlatković, Sasa, Nikolić, Vesna D., Nikolić, Goran, Binić, Ivana, "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study" in Forschende Komplementarmedizin, 19, no. 1 (2012):26-30, https://doi.org/10.1159/000335786 . .