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dc.creatorŽivković, Jelena
dc.creatorCebović, Tatjana
dc.creatorMaksimović, Zoran
dc.date.accessioned2019-09-02T11:29:04Z
dc.date.available2019-09-02T11:29:04Z
dc.date.issued2012
dc.identifier.issn1895-104X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1707
dc.description.abstractThe aim of the present study was to examine the antioxidant activity of three Veronica species (Plantaginaceae). The antioxidant potential of various extracts obtained from aerial flowering parts was evaluated by DPPH-free (1,1-diphenyl-2-picrylhydrazyl-free) radical scavenging activity and ferric-reducing antioxidant power assays. Considerable antioxidant activity was observed in the plant samples (FRAP values ranged from 0.97 to 4.85 mmol Fe2+/g, and DPPH IC50 values from 12.58 to 66.34 A mu g/ml); however, these levels were lower than the activity of the control compound butylated hydroxytoluene (BHT) (FRAP: 10.58 mmol Fe2+/g; DPPH IC50: 9.57 A mu g/ml). Also, the in vivo antioxidant effects were evaluated in several hepatic antioxidant systems in rats (activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase, glutathione content and level of thiobarbituric acid reactive substances) after treatment with different Veronica extracts, or in combination with carbon tetrachloride (CCl4). Pretreatment with 100 mg/kg b.w. of Veronica extracts inhibited CCl4-induced liver injury by decreasing TBA-RS level, increasing GSH content, and bringing the activities of CAT and Px to control levels. The present study suggests that the extracts analyzed could protect the liver cells from CCl4-induced liver damage by their antioxidative effect on hepatocytes.en
dc.publisherVersita, Warsaw
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143012/RS//
dc.rightsopenAccess
dc.sourceCentral European Journal of Biology
dc.subjectAntioxidant activityen
dc.subjectVeronica speciesen
dc.subjectCarbon tetrachlorideen
dc.subjectLipid peroxidationen
dc.subjectBiochemical parametersen
dc.titleIn vivo and in vitro antioxidant effects of three Veronica speciesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦебовић, Татјана; Живковић, Јелена; Максимовић, Зоран;
dc.citation.volume7
dc.citation.issue3
dc.citation.spage559
dc.citation.epage568
dc.citation.other7(3): 559-568
dc.citation.rankM23
dc.identifier.wos000302476900020
dc.identifier.doi10.2478/s11535-012-0041-4
dc.identifier.scopus2-s2.0-84859327011
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/526/1705.pdf
dc.identifier.rcubconv_2617
dc.type.versionpublishedVersion


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