FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil

Authorized Users Only
2012
Authors
Pavlović, Ivan
Petrović, Silvana
Radenković, Mirjana
Milenković, Marina
Couladis, Maria
Branković, Suzana
Drobac, Milica
Niketić, Marjan
Article (Published version)
Metadata
Show full item record
Abstract
The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 mu g/ml), as well as against Micrococcus luteus (MIC = 13.7 mu g/ml), Staphylococcus epidermidis (MIC = 17.6 mu g/ml), Bacillus subtilis (MIC = 21.1 mu g/ml) and Micrococcus flavus (MIC = 28.2 mu g/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC(50) = 22.43 mu l/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 mu g/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 mu g/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 mu g/ml, the essenti...al oil almost completely abolished the spasmodic effect of potassium chloride (80 mM).

Keywords:
Ferula heuffelii / Essential oil composition / Antimicrobial activity / Antiradical activity / Antispasmodic activity
Source:
Food Chemistry, 2012, 130, 2, 310-315
Publisher:
  • Elsevier Sci Ltd, Oxford
Funding / projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1016/j.foodchem.2011.07.043

ISSN: 0308-8146

WoS: 000296267400013

Scopus: 2-s2.0-80052273360
[ Google Scholar ]
33
32
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1715
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Pavlović, Ivan
AU  - Petrović, Silvana
AU  - Radenković, Mirjana
AU  - Milenković, Marina
AU  - Couladis, Maria
AU  - Branković, Suzana
AU  - Drobac, Milica
AU  - Niketić, Marjan
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1715
AB  - The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 mu g/ml), as well as against Micrococcus luteus (MIC = 13.7 mu g/ml), Staphylococcus epidermidis (MIC = 17.6 mu g/ml), Bacillus subtilis (MIC = 21.1 mu g/ml) and Micrococcus flavus (MIC = 28.2 mu g/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC(50) = 22.43 mu l/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 mu g/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 mu g/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 mu g/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM).
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil
VL  - 130
IS  - 2
SP  - 310
EP  - 315
DO  - 10.1016/j.foodchem.2011.07.043
ER  - 
@article{
author = "Pavlović, Ivan and Petrović, Silvana and Radenković, Mirjana and Milenković, Marina and Couladis, Maria and Branković, Suzana and Drobac, Milica and Niketić, Marjan",
year = "2012",
abstract = "The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 mu g/ml), as well as against Micrococcus luteus (MIC = 13.7 mu g/ml), Staphylococcus epidermidis (MIC = 17.6 mu g/ml), Bacillus subtilis (MIC = 21.1 mu g/ml) and Micrococcus flavus (MIC = 28.2 mu g/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC(50) = 22.43 mu l/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 mu g/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 mu g/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 mu g/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM).",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil",
volume = "130",
number = "2",
pages = "310-315",
doi = "10.1016/j.foodchem.2011.07.043"
}
Pavlović, I., Petrović, S., Radenković, M., Milenković, M., Couladis, M., Branković, S., Drobac, M.,& Niketić, M.. (2012). Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. in Food Chemistry
Elsevier Sci Ltd, Oxford., 130(2), 310-315.
https://doi.org/10.1016/j.foodchem.2011.07.043
Pavlović I, Petrović S, Radenković M, Milenković M, Couladis M, Branković S, Drobac M, Niketić M. Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. in Food Chemistry. 2012;130(2):310-315.
doi:10.1016/j.foodchem.2011.07.043 .
Pavlović, Ivan, Petrović, Silvana, Radenković, Mirjana, Milenković, Marina, Couladis, Maria, Branković, Suzana, Drobac, Milica, Niketić, Marjan, "Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil" in Food Chemistry, 130, no. 2 (2012):310-315,
https://doi.org/10.1016/j.foodchem.2011.07.043 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB