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dc.creatorSimić-Ogrizović, Sanja
dc.creatorBogavac-Stanojević, Nataša
dc.creatorVucković, Maja
dc.creatorDopsaj, Violeta
dc.creatorGiga, Vojislav
dc.creatorKravljaca, Milica
dc.creatorStošović, Milan
dc.creatorLezaić, Višnja
dc.date.accessioned2019-09-02T11:29:24Z
dc.date.available2019-09-02T11:29:24Z
dc.date.issued2012
dc.identifier.issn0040-8727
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1719
dc.description.abstractThe best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p lt 0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.en
dc.publisherTohoku Univ Medical Press, Sendai
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175089/RS//
dc.rightsopenAccess
dc.sourceToxicological and Environmental Chemistry
dc.subjectchronic kidney diseaseen
dc.subjectcoronary artery calcificationen
dc.subjectfetuin Aen
dc.subjectinflammationen
dc.subjectrenal transplant recipienten
dc.titleRisk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДопсај, Виолета; Симић-Огризовић, Сања; Лезаић, Вишња; Крављаца, Милица; Гига, Војислав; Вуцковић, Маја; Богавац-Станојевић, Наташа; Стошовић, Милан;
dc.citation.volume226
dc.citation.issue2
dc.citation.spage137
dc.citation.epage144
dc.citation.other226(2): 137-144
dc.citation.rankM22
dc.identifier.wos000300761500007
dc.identifier.doi10.1620/tjem.226.137
dc.identifier.pmid22293651
dc.identifier.scopus2-s2.0-84866048129
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/534/1717.pdf
dc.type.versionpublishedVersion


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