Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study
Authorized Users Only
2012
Authors
Pantelić, Ivana
Lukić, Milica

Malenović, Anđelija

Reichl, Stephan

Hoffmann, Christine
Mueller-Goymann, Christel
Daniels, Rolf
Savić, Snežana

Article (Published version)

Metadata
Show full item recordAbstract
Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles ...from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.
Keywords:
Alkyl polyglucosides / Ketoprofen / Ready-to-use bases / Isopropyl alcohol / Tape stripping / Skin performanceSource:
European Journal of Pharmaceutics and Biopharmaceutics, 2012, 80, 1, 164-175Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.ejpb.2011.09.001
ISSN: 0939-6411
PubMed: 21939763
WoS: 000299495400022
Scopus: 2-s2.0-83955162903
Collections
Institution/Community
PharmacyTY - JOUR AU - Pantelić, Ivana AU - Lukić, Milica AU - Malenović, Anđelija AU - Reichl, Stephan AU - Hoffmann, Christine AU - Mueller-Goymann, Christel AU - Daniels, Rolf AU - Savić, Snežana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1721 AB - Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones. PB - Elsevier Science BV, Amsterdam T2 - European Journal of Pharmaceutics and Biopharmaceutics T1 - Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study VL - 80 IS - 1 SP - 164 EP - 175 DO - 10.1016/j.ejpb.2011.09.001 ER -
@article{ author = "Pantelić, Ivana and Lukić, Milica and Malenović, Anđelija and Reichl, Stephan and Hoffmann, Christine and Mueller-Goymann, Christel and Daniels, Rolf and Savić, Snežana", year = "2012", abstract = "Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.", publisher = "Elsevier Science BV, Amsterdam", journal = "European Journal of Pharmaceutics and Biopharmaceutics", title = "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study", volume = "80", number = "1", pages = "164-175", doi = "10.1016/j.ejpb.2011.09.001" }
Pantelić, I., Lukić, M., Malenović, A., Reichl, S., Hoffmann, C., Mueller-Goymann, C., Daniels, R.,& Savić, S.. (2012). Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics Elsevier Science BV, Amsterdam., 80(1), 164-175. https://doi.org/10.1016/j.ejpb.2011.09.001
Pantelić I, Lukić M, Malenović A, Reichl S, Hoffmann C, Mueller-Goymann C, Daniels R, Savić S. Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics. 2012;80(1):164-175. doi:10.1016/j.ejpb.2011.09.001 .
Pantelić, Ivana, Lukić, Milica, Malenović, Anđelija, Reichl, Stephan, Hoffmann, Christine, Mueller-Goymann, Christel, Daniels, Rolf, Savić, Snežana, "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study" in European Journal of Pharmaceutics and Biopharmaceutics, 80, no. 1 (2012):164-175, https://doi.org/10.1016/j.ejpb.2011.09.001 . .