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dc.creatorPantelić, Ivana
dc.creatorLukić, Milica
dc.creatorMalenović, Anđelija
dc.creatorReichl, Stephan
dc.creatorHoffmann, Christine
dc.creatorMueller-Goymann, Christel
dc.creatorDaniels, Rolf
dc.creatorSavić, Snežana
dc.date.accessioned2019-09-02T11:29:25Z
dc.date.available2019-09-02T11:29:25Z
dc.date.issued2012
dc.identifier.issn0939-6411
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1721
dc.description.abstractRecently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.subjectAlkyl polyglucosidesen
dc.subjectKetoprofenen
dc.subjectReady-to-use basesen
dc.subjectIsopropyl alcoholen
dc.subjectTape strippingen
dc.subjectSkin performanceen
dc.titleCompounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаленовић, Aнђелија; Лукић, Милица; Савић, Снежана; Хоффманн, Цхристине; Реицхл, Степхан; Даниелс, Ролф; Пантелић, Ивана; Муеллер-Гоyманн, Цхристел;
dc.citation.volume80
dc.citation.issue1
dc.citation.spage164
dc.citation.epage175
dc.citation.other80(1): 164-175
dc.citation.rankM21
dc.identifier.wos000299495400022
dc.identifier.doi10.1016/j.ejpb.2011.09.001
dc.identifier.pmid21939763
dc.identifier.scopus2-s2.0-83955162903
dc.identifier.rcubconv_2578
dc.type.versionpublishedVersion


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