Densitometric determination of metoprolol tartrate in pharmaceutical dosage forms
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This paper describes a simple densitometric method for the determination of metroprolol tartrate in tablets and ampoules. After separation on silica gel GF254 plates, using acetone-methanol-triethylamine as the mobile phase for the tablets and acetone-triethylamine for ampoules, the chromatographic zones corresponding to the spots of metoprolol were scanned. Quantitation was performed using a computer-controlled Camag TLC scanner and applying five-point calibration with polynomial regression. The calibration function was established in the ranges 1-28 mu g for tablets and 1-9 mu g for ampoules. The results obtained are precise and reproducible, with recovery values of 99.1-99.4%.
Source:Journal of Pharmaceutical and Biomedical Analysis, 1997, 15, 5, 581-585
- Pergamon-Elsevier Science Ltd, Oxford