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dc.creatorNovaković, Aleksandra
dc.creatorPavlović, Marija
dc.creatorMilojević, Predrag
dc.creatorStojanović, Ivan
dc.creatorNenezić, Dragoslav
dc.creatorJović, Miomir
dc.creatorUgrešić, Nenad
dc.creatorKanjuh, Vladimir
dc.creatorYang, Qin
dc.creatorHe, Guo-Wei
dc.date.accessioned2019-09-02T11:29:40Z
dc.date.available2019-09-02T11:29:40Z
dc.date.issued2012
dc.identifier.issn1742-7835
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1731
dc.description.abstractThe ATP-sensitive K+ channels opener (KATPCO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N?-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K+ (KATP) channels. In addition to the well-known effect on the opening of KATP channels, it has been reported that vasorelaxation induced by some of the KATPCOs includes some other K+ channel subtypes. Given that there is still no information on other types of K+ channels possibly involved in the mechanism of relaxation induced by P1075, this study was designed to examine the effects of P1075 on the rat renal artery with endothelium and with denuded endothelium and to define the contribution of different K+ channel subtypes in the P1075 action on this blood vessel. Our results show that P1075 induced a concentration-dependent relaxation of rat renal artery rings pre-contracted by phenylephrine. Glibenclamide, a selective KATP channels inhibitor, partly antagonized the relaxation of rat renal artery induced by P1075. Tetraethylammonium (TEA), a non-selective inhibitor of Ca2+-activated K+ channels, as well as iberiotoxin, a most selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, did not abolish the effect of P1075 on rat renal artery. In contrast, a non-selective blocker of voltage-gated K+ (KV) channels, 4-aminopyridine (4-AP), as well as margatoxin, a potent inhibitor of KV1.3 channels, caused partial inhibition of the P1075-induced relaxation of rat renal artery. In addition, in this study, P1075 relaxed contractions induced by 20 similar to mM K+, but had no effect on contractions induced by 80 similar to mM K+. Our results showed that P1075 induced strong endothelium-independent relaxation of rat renal artery. It seems that KATP, 4-AP- and margatoxin-sensitive K+ channels located in vascular smooth muscle mediated the relaxation of rat renal artery induced by P1075.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175088/RS//
dc.rightsrestrictedAccess
dc.sourceBasic & Clinical Pharmacology & Toxicology
dc.titleDifferent Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНоваковић, Aлександра; Милојевић, Предраг; Хе, Гуо-Wеи; Yанг, Qин; Стојановић, Иван; Угрешић, Ненад; Јовић, Миомир; Кањух, Владимир; Ненезић, Драгослав; Павловић, Марија;
dc.citation.volume111
dc.citation.issue1
dc.citation.spage24
dc.citation.epage30
dc.citation.other111(1): 24-30
dc.citation.rankM22
dc.identifier.wos000305508600005
dc.identifier.doi10.1111/j.1742-7843.2011.00855.x
dc.identifier.pmid22225832
dc.identifier.scopus2-s2.0-84862705509
dc.identifier.rcubconv_2652
dc.type.versionpublishedVersion


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