TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals
Abstract
A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and VIII, was performed on silica gel 60F(254) HPTLC plates using methylene chloride-methanol-concentrated ammonia, 9:1.6:0.1 (v/v) as mobile phase. Detection was performed at 240 nm. All validation requirements, specificity, linearity (r >= 0.997), recovery (95.08-100.39%), limit of quantification (0.1-0.2%), and robustness were examined and fulfilled, and the proposed method can be successfully applied for the quality control analysis of commercially available tablets and injections.
Keywords:
dosage forms / HPTLC / impurities / pharmaceutical preparations / quantification / tiapride hydrochlorideSource:
Journal of Liquid Chromatography & Related Technologies, 2012, 35, 10, 1336-1345Publisher:
- Taylor & Francis Inc, Philadelphia
Funding / projects:
DOI: 10.1080/10826076.2012.675870
ISSN: 1082-6076
WoS: 000305566500007
Scopus: 2-s2.0-84862980565
Collections
Institution/Community
PharmacyTY - JOUR AU - Ranković, Katarina AU - Filipić, Slavica AU - Nikolić, Katarina AU - Agbaba, Danica PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1732 AB - A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and VIII, was performed on silica gel 60F(254) HPTLC plates using methylene chloride-methanol-concentrated ammonia, 9:1.6:0.1 (v/v) as mobile phase. Detection was performed at 240 nm. All validation requirements, specificity, linearity (r >= 0.997), recovery (95.08-100.39%), limit of quantification (0.1-0.2%), and robustness were examined and fulfilled, and the proposed method can be successfully applied for the quality control analysis of commercially available tablets and injections. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography & Related Technologies T1 - TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals VL - 35 IS - 10 SP - 1336 EP - 1345 DO - 10.1080/10826076.2012.675870 ER -
@article{ author = "Ranković, Katarina and Filipić, Slavica and Nikolić, Katarina and Agbaba, Danica", year = "2012", abstract = "A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and VIII, was performed on silica gel 60F(254) HPTLC plates using methylene chloride-methanol-concentrated ammonia, 9:1.6:0.1 (v/v) as mobile phase. Detection was performed at 240 nm. All validation requirements, specificity, linearity (r >= 0.997), recovery (95.08-100.39%), limit of quantification (0.1-0.2%), and robustness were examined and fulfilled, and the proposed method can be successfully applied for the quality control analysis of commercially available tablets and injections.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography & Related Technologies", title = "TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals", volume = "35", number = "10", pages = "1336-1345", doi = "10.1080/10826076.2012.675870" }
Ranković, K., Filipić, S., Nikolić, K.,& Agbaba, D.. (2012). TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc, Philadelphia., 35(10), 1336-1345. https://doi.org/10.1080/10826076.2012.675870
Ranković K, Filipić S, Nikolić K, Agbaba D. TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals. in Journal of Liquid Chromatography & Related Technologies. 2012;35(10):1336-1345. doi:10.1080/10826076.2012.675870 .
Ranković, Katarina, Filipić, Slavica, Nikolić, Katarina, Agbaba, Danica, "TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals" in Journal of Liquid Chromatography & Related Technologies, 35, no. 10 (2012):1336-1345, https://doi.org/10.1080/10826076.2012.675870 . .