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TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals

Authorized Users Only
2012
Authors
Ranković, Katarina
Filipić, Slavica
Nikolić, Katarina
Agbaba, Danica
Article (Published version)
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Abstract
A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and VIII, was performed on silica gel 60F(254) HPTLC plates using methylene chloride-methanol-concentrated ammonia, 9:1.6:0.1 (v/v) as mobile phase. Detection was performed at 240 nm. All validation requirements, specificity, linearity (r >= 0.997), recovery (95.08-100.39%), limit of quantification (0.1-0.2%), and robustness were examined and fulfilled, and the proposed method can be successfully applied for the quality control analysis of commercially available tablets and injections.
Keywords:
dosage forms / HPTLC / impurities / pharmaceutical preparations / quantification / tiapride hydrochloride
Source:
Journal of Liquid Chromatography & Related Technologies, 2012, 35, 10, 1336-1345
Publisher:
  • Taylor & Francis Inc, Philadelphia
Funding / projects:
  • Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-172033)

DOI: 10.1080/10826076.2012.675870

ISSN: 1082-6076

WoS: 000305566500007

Scopus: 2-s2.0-84862980565
[ Google Scholar ]
1
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1732
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ranković, Katarina
AU  - Filipić, Slavica
AU  - Nikolić, Katarina
AU  - Agbaba, Danica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1732
AB  - A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and VIII, was performed on silica gel 60F(254) HPTLC plates using methylene chloride-methanol-concentrated ammonia, 9:1.6:0.1 (v/v) as mobile phase. Detection was performed at 240 nm. All validation requirements, specificity, linearity (r >= 0.997), recovery (95.08-100.39%), limit of quantification (0.1-0.2%), and robustness were examined and fulfilled, and the proposed method can be successfully applied for the quality control analysis of commercially available tablets and injections.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals
VL  - 35
IS  - 10
SP  - 1336
EP  - 1345
DO  - 10.1080/10826076.2012.675870
ER  - 
@article{
author = "Ranković, Katarina and Filipić, Slavica and Nikolić, Katarina and Agbaba, Danica",
year = "2012",
abstract = "A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and VIII, was performed on silica gel 60F(254) HPTLC plates using methylene chloride-methanol-concentrated ammonia, 9:1.6:0.1 (v/v) as mobile phase. Detection was performed at 240 nm. All validation requirements, specificity, linearity (r >= 0.997), recovery (95.08-100.39%), limit of quantification (0.1-0.2%), and robustness were examined and fulfilled, and the proposed method can be successfully applied for the quality control analysis of commercially available tablets and injections.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals",
volume = "35",
number = "10",
pages = "1336-1345",
doi = "10.1080/10826076.2012.675870"
}
Ranković, K., Filipić, S., Nikolić, K.,& Agbaba, D.. (2012). TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 35(10), 1336-1345.
https://doi.org/10.1080/10826076.2012.675870
Ranković K, Filipić S, Nikolić K, Agbaba D. TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals. in Journal of Liquid Chromatography & Related Technologies. 2012;35(10):1336-1345.
doi:10.1080/10826076.2012.675870 .
Ranković, Katarina, Filipić, Slavica, Nikolić, Katarina, Agbaba, Danica, "TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals" in Journal of Liquid Chromatography & Related Technologies, 35, no. 10 (2012):1336-1345,
https://doi.org/10.1080/10826076.2012.675870 . .

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