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dc.creatorDimitrijević, Mirjana
dc.creatorStanojević, Stanislava
dc.creatorKustrimović, Nataša
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:29:48Z
dc.date.available2019-09-02T11:29:48Z
dc.date.issued2012
dc.identifier.issn0257-277X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1737
dc.description.abstractMuch evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceImmunologic Research
dc.subjectGlucocorticoidsen
dc.subjectCatecholaminesen
dc.subjectNeuropeptide Yen
dc.subjectThymocyte negative selectionen
dc.subjectT regulatory cellsen
dc.subjectMacrophagesen
dc.subjectAutoimmune diseasesen
dc.subjectExperimental autoimmune encephalomyelitisen
dc.titleEnd-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathologyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанојевић, Станислава; Димитријевић, Мирјана; Кустримовић, Наташа; Лепосавић, Гордана;
dc.citation.volume52
dc.citation.issue1-2
dc.citation.spage64
dc.citation.epage80
dc.citation.other52(1-2): 64-80
dc.citation.rankM22
dc.identifier.wos000303057600008
dc.identifier.doi10.1007/s12026-012-8275-9
dc.identifier.pmid22396175
dc.identifier.scopus2-s2.0-84859917679
dc.identifier.rcubconv_2625
dc.type.versionpublishedVersion


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