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Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes

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Authors
Aleksić, Mara
Radulović, Valentina
Lijeskić, Nikola
Kapetanović, Vera
Article (Published version)
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Abstract
The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6...) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.

Keywords:
Boron doped diamond electrode / Glassy carbon electrode / Hanging mercury drop electrode / Plasma / Reduction / Varenicline
Source:
Current Analytical Chemistry, 2012, 8, 1, 133-142
Publisher:
  • Bentham Science Publ Ltd, Sharjah
Funding / projects:
  • Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-172033)

ISSN: 1573-4110

WoS: 000300391000011

Scopus: 2-s2.0-84855289194
[ Google Scholar ]
18
16
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1739
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1739
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Aleksić, Mara
AU  - Radulović, Valentina
AU  - Lijeskić, Nikola
AU  - Kapetanović, Vera
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1739
AB  - The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Analytical Chemistry
T1  - Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes
VL  - 8
IS  - 1
SP  - 133
EP  - 142
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1739
ER  - 
@article{
author = "Aleksić, Mara and Radulović, Valentina and Lijeskić, Nikola and Kapetanović, Vera",
year = "2012",
abstract = "The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Analytical Chemistry",
title = "Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes",
volume = "8",
number = "1",
pages = "133-142",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1739"
}
Aleksić, M., Radulović, V., Lijeskić, N.,& Kapetanović, V.. (2012). Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes. in Current Analytical Chemistry
Bentham Science Publ Ltd, Sharjah., 8(1), 133-142.
https://hdl.handle.net/21.15107/rcub_farfar_1739
Aleksić M, Radulović V, Lijeskić N, Kapetanović V. Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes. in Current Analytical Chemistry. 2012;8(1):133-142.
https://hdl.handle.net/21.15107/rcub_farfar_1739 .
Aleksić, Mara, Radulović, Valentina, Lijeskić, Nikola, Kapetanović, Vera, "Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes" in Current Analytical Chemistry, 8, no. 1 (2012):133-142,
https://hdl.handle.net/21.15107/rcub_farfar_1739 .

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