FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain

Authorized Users Only
1998
Authors
Jokanović, Milan
Stepanović-Petrović, Radica
Maksimović, Matej
Kosanović, Melita
Stojiljković, Miloš P.
Article (Published version)
Metadata
Show full item record
Abstract
This study was aimed to investigate the possibility of modifying the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase (NTE) of hen blain. This reaction on NTE occurs with a half-time of 7.4 min. Atropine was effective in decreasing the rate of aging on DFP-inhibited NTE and this effect was time-and concentration-dependent. Atropine was also a weak but progressive inhibitor of NTE activity (I-50 = 80 mM) and this reaction appears to be reversible at lower atropine concentrations. Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. However, when atropine and oximes were used together we have obtained a potentiating and/or synergistic effect which was most significant with combination of atropine and TMB-4 giving up to a 15-fold decrease in th...e rate of aging reaction. The efficacy of this particular combination was concentration-dependent. We have also discussed similarities and differences in aging reaction occurring on NTE and AChE.

Keywords:
Organophosphate-induced delayed polyneuropathy / Organophosphates / Oximes / Atropine
Source:
Toxicology Letters, 1998, 95, 2, 93-101
Publisher:
  • Elsevier Sci Ireland Ltd, Clare

DOI: 10.1016/S0378-4274(98)00017-4

ISSN: 0378-4274

PubMed: 9635412

WoS: 000074184100003

Scopus: 2-s2.0-0032536756
[ Google Scholar ]
8
8
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/174
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Jokanović, Milan
AU  - Stepanović-Petrović, Radica
AU  - Maksimović, Matej
AU  - Kosanović, Melita
AU  - Stojiljković, Miloš P.
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/174
AB  - This study was aimed to investigate the possibility of modifying the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase (NTE) of hen blain. This reaction on NTE occurs with a half-time of 7.4 min. Atropine was effective in decreasing the rate of aging on DFP-inhibited NTE and this effect was time-and concentration-dependent. Atropine was also a weak but progressive inhibitor of NTE activity (I-50 = 80 mM) and this reaction appears to be reversible at lower atropine concentrations. Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. However, when atropine and oximes were used together we have obtained a potentiating and/or synergistic effect which was most significant with combination of atropine and TMB-4 giving up to a 15-fold decrease in the rate of aging reaction. The efficacy of this particular combination was concentration-dependent. We have also discussed similarities and differences in aging reaction occurring on NTE and AChE.
PB  - Elsevier Sci Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain
VL  - 95
IS  - 2
SP  - 93
EP  - 101
DO  - 10.1016/S0378-4274(98)00017-4
ER  - 
@article{
author = "Jokanović, Milan and Stepanović-Petrović, Radica and Maksimović, Matej and Kosanović, Melita and Stojiljković, Miloš P.",
year = "1998",
abstract = "This study was aimed to investigate the possibility of modifying the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase (NTE) of hen blain. This reaction on NTE occurs with a half-time of 7.4 min. Atropine was effective in decreasing the rate of aging on DFP-inhibited NTE and this effect was time-and concentration-dependent. Atropine was also a weak but progressive inhibitor of NTE activity (I-50 = 80 mM) and this reaction appears to be reversible at lower atropine concentrations. Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. However, when atropine and oximes were used together we have obtained a potentiating and/or synergistic effect which was most significant with combination of atropine and TMB-4 giving up to a 15-fold decrease in the rate of aging reaction. The efficacy of this particular combination was concentration-dependent. We have also discussed similarities and differences in aging reaction occurring on NTE and AChE.",
publisher = "Elsevier Sci Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain",
volume = "95",
number = "2",
pages = "93-101",
doi = "10.1016/S0378-4274(98)00017-4"
}
Jokanović, M., Stepanović-Petrović, R., Maksimović, M., Kosanović, M.,& Stojiljković, M. P.. (1998). Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain. in Toxicology Letters
Elsevier Sci Ireland Ltd, Clare., 95(2), 93-101.
https://doi.org/10.1016/S0378-4274(98)00017-4
Jokanović M, Stepanović-Petrović R, Maksimović M, Kosanović M, Stojiljković MP. Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain. in Toxicology Letters. 1998;95(2):93-101.
doi:10.1016/S0378-4274(98)00017-4 .
Jokanović, Milan, Stepanović-Petrović, Radica, Maksimović, Matej, Kosanović, Melita, Stojiljković, Miloš P., "Modification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brain" in Toxicology Letters, 95, no. 2 (1998):93-101,
https://doi.org/10.1016/S0378-4274(98)00017-4 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB