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dc.creatorBulat, Zorica
dc.creatorĐukić-Ćosić, Danijela
dc.creatorAntonijević, Biljana
dc.creatorBulat, Petar
dc.creatorVujanović, Dragana
dc.creatorBuha, Aleksandra
dc.creatorMatović, Vesna
dc.date.accessioned2019-09-02T11:30:00Z
dc.date.available2019-09-02T11:30:00Z
dc.date.issued2012
dc.identifier.issn1537-744X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1743
dc.description.abstractThe present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO3 and HClO4 (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.en
dc.publisherHindawi Publishing Corporation, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccess
dc.sourceSensors
dc.titleEffect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxicationen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЂукић-Ћосић, Данијела; Вујановић, Драгана; Матовић, Весна; Булат, Петар; Булат, Зорица; Буха, Aлександра; Aнтонијевић, Биљана;
dc.citation.rankM21
dc.identifier.wos000307478000001
dc.identifier.doi10.1100/2012/572514
dc.identifier.pmid22701362
dc.identifier.scopus2-s2.0-84863739441
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/555/1741.pdf
dc.identifier.rcubconv_2670
dc.type.versionpublishedVersion


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