Development and optimization of formulation for treatment of copper deficiency in human organism
Само за регистроване кориснике
2012
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation technique, are containg active substance, a copper(II) complex with polysaccharide pullulan. The binder concentration, the disintegrant concentration and the resistance to crushing were used as independent variables in the formulation; while in vitro measured drug release characteristics of the tablets was response variable in a full factorial design 2(3) modeling. A cubic model for data fitted was used to examine the obtained results. They showed that the resistance to crushing has the most significant effect on copper(II) complex release from the formulation, while the disintegrant concentration has smaller influence on dissolution profile of copper(II) complex and the binder concentration had minor impact in this study. Lower value of resistance to crushing has influe...nce on better dissolution profile. Furthermore, physical characteristics of the tablets were evaluated, viz., drug content, hardness, thickness, friability, disintegration time, mass variation, particle size and size distribution.
Кључне речи:
copper / experimental design / dissolution / profileИзвор:
Acta Poloniae Pharmaceutica - Drug Research, 2012, 69, 4, 739-749Издавач:
- Polskie Towarzystwo Farmaceutyczne, Warsaw
Финансирање / пројекти:
- Биљни и синтетички биоактивни производи новије генерације (RS-MESTD-Technological Development (TD or TR)-34012)
Институција/група
PharmacyTY - JOUR AU - Savić, Ivana AU - Nikolić, Goran AU - Savić, Ivan AU - Nikolić, Katarina AU - Agbaba, Danica PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1744 AB - The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation technique, are containg active substance, a copper(II) complex with polysaccharide pullulan. The binder concentration, the disintegrant concentration and the resistance to crushing were used as independent variables in the formulation; while in vitro measured drug release characteristics of the tablets was response variable in a full factorial design 2(3) modeling. A cubic model for data fitted was used to examine the obtained results. They showed that the resistance to crushing has the most significant effect on copper(II) complex release from the formulation, while the disintegrant concentration has smaller influence on dissolution profile of copper(II) complex and the binder concentration had minor impact in this study. Lower value of resistance to crushing has influence on better dissolution profile. Furthermore, physical characteristics of the tablets were evaluated, viz., drug content, hardness, thickness, friability, disintegration time, mass variation, particle size and size distribution. PB - Polskie Towarzystwo Farmaceutyczne, Warsaw T2 - Acta Poloniae Pharmaceutica - Drug Research T1 - Development and optimization of formulation for treatment of copper deficiency in human organism VL - 69 IS - 4 SP - 739 EP - 749 UR - https://hdl.handle.net/21.15107/rcub_farfar_1744 ER -
@article{ author = "Savić, Ivana and Nikolić, Goran and Savić, Ivan and Nikolić, Katarina and Agbaba, Danica", year = "2012", abstract = "The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation technique, are containg active substance, a copper(II) complex with polysaccharide pullulan. The binder concentration, the disintegrant concentration and the resistance to crushing were used as independent variables in the formulation; while in vitro measured drug release characteristics of the tablets was response variable in a full factorial design 2(3) modeling. A cubic model for data fitted was used to examine the obtained results. They showed that the resistance to crushing has the most significant effect on copper(II) complex release from the formulation, while the disintegrant concentration has smaller influence on dissolution profile of copper(II) complex and the binder concentration had minor impact in this study. Lower value of resistance to crushing has influence on better dissolution profile. Furthermore, physical characteristics of the tablets were evaluated, viz., drug content, hardness, thickness, friability, disintegration time, mass variation, particle size and size distribution.", publisher = "Polskie Towarzystwo Farmaceutyczne, Warsaw", journal = "Acta Poloniae Pharmaceutica - Drug Research", title = "Development and optimization of formulation for treatment of copper deficiency in human organism", volume = "69", number = "4", pages = "739-749", url = "https://hdl.handle.net/21.15107/rcub_farfar_1744" }
Savić, I., Nikolić, G., Savić, I., Nikolić, K.,& Agbaba, D.. (2012). Development and optimization of formulation for treatment of copper deficiency in human organism. in Acta Poloniae Pharmaceutica - Drug Research Polskie Towarzystwo Farmaceutyczne, Warsaw., 69(4), 739-749. https://hdl.handle.net/21.15107/rcub_farfar_1744
Savić I, Nikolić G, Savić I, Nikolić K, Agbaba D. Development and optimization of formulation for treatment of copper deficiency in human organism. in Acta Poloniae Pharmaceutica - Drug Research. 2012;69(4):739-749. https://hdl.handle.net/21.15107/rcub_farfar_1744 .
Savić, Ivana, Nikolić, Goran, Savić, Ivan, Nikolić, Katarina, Agbaba, Danica, "Development and optimization of formulation for treatment of copper deficiency in human organism" in Acta Poloniae Pharmaceutica - Drug Research, 69, no. 4 (2012):739-749, https://hdl.handle.net/21.15107/rcub_farfar_1744 .