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dc.creatorĐuriš, Jelena
dc.creatorMedarević, Đorđe
dc.creatorKrstić, Marko
dc.creatorVasiljević, Ivana
dc.creatorMašić, Ivana
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:30:02Z
dc.date.available2019-09-02T11:30:02Z
dc.date.issued2012
dc.identifier.issn1537-744X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1745
dc.description.abstractThe aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters. They were varied in the first set of experiments in order to estimate their influences on critical quality attributes, that is, granules characteristics (size distribution, flowability, bulk density, tapped density, Carr's index, Hausner's ratio, and moisture content) using Plackett-Burman experimental design. Type of diluent and atomization pressure were selected as the most important parameters. In the second set of experiments, design space for process parameters (atomization pressure and compression force) and its influence on tablets characteristics was developed. Percent of paracetamol released and tablets hardness were determined as critical quality attributes. Artificial neural networks (ANNs) were applied in order to determine design space. ANNs models showed that atomization pressure influences mostly on the dissolution profile, whereas compression force affects mainly the tablets hardness. Based on the obtained ANNs models, it is possible to predict tablet hardness and paracetamol release profile for any combination of analyzed factors.en
dc.publisherHindawi Publishing Corporation, New York
dc.rightsopenAccess
dc.sourceSensors
dc.titleDesign Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Processen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractКрстић, Марко; Ибрић, Светлана; Ђуриш, Јелена; Медаревић, Ђорђе; Васиљевић, Ивана; Машић, Ивана;
dc.citation.rankM21
dc.identifier.wos000307743100001
dc.identifier.doi10.1100/2012/185085
dc.identifier.pmid22919295
dc.identifier.scopus2-s2.0-84864917117
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/556/1743.pdf
dc.identifier.rcubconv_2672
dc.type.versionpublishedVersion


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