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Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats

Authorized Users Only
2012
Authors
Cebović, Tatjana
Maksimović, Zoran
Article (Published version)
Metadata
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Abstract
The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright
Keywords:
Filipendula hexapetala / flowers / methanol extract / hepatoprotective activity
Source:
Phytotherapy Research, 2012, 26, 7, 1088-1091
Publisher:
  • Wiley-Blackwell, Hoboken
Funding / projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1002/ptr.3703

ISSN: 0951-418X

PubMed: 22213368

WoS: 000306085700022

Scopus: 2-s2.0-84863715953
[ Google Scholar ]
7
7
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1746
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Cebović, Tatjana
AU  - Maksimović, Zoran
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1746
AB  - The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Phytotherapy Research
T1  - Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats
VL  - 26
IS  - 7
SP  - 1088
EP  - 1091
DO  - 10.1002/ptr.3703
ER  - 
@article{
author = "Cebović, Tatjana and Maksimović, Zoran",
year = "2012",
abstract = "The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytotherapy Research",
title = "Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats",
volume = "26",
number = "7",
pages = "1088-1091",
doi = "10.1002/ptr.3703"
}
Cebović, T.,& Maksimović, Z.. (2012). Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. in Phytotherapy Research
Wiley-Blackwell, Hoboken., 26(7), 1088-1091.
https://doi.org/10.1002/ptr.3703
Cebović T, Maksimović Z. Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. in Phytotherapy Research. 2012;26(7):1088-1091.
doi:10.1002/ptr.3703 .
Cebović, Tatjana, Maksimović, Zoran, "Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats" in Phytotherapy Research, 26, no. 7 (2012):1088-1091,
https://doi.org/10.1002/ptr.3703 . .

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