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dc.creatorJokanović, Milan
dc.creatorStepanović-Petrović, Radica
dc.creatorMaksimović, Matej
dc.creatorKosanović, Melita
dc.creatorStojiljković, Miloš P.
dc.date.accessioned2019-09-02T10:50:20Z
dc.date.available2019-09-02T10:50:20Z
dc.date.issued1998
dc.identifier.issn0378-4274
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/174
dc.description.abstractThis study was aimed to investigate the possibility of modifying the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase (NTE) of hen blain. This reaction on NTE occurs with a half-time of 7.4 min. Atropine was effective in decreasing the rate of aging on DFP-inhibited NTE and this effect was time-and concentration-dependent. Atropine was also a weak but progressive inhibitor of NTE activity (I-50 = 80 mM) and this reaction appears to be reversible at lower atropine concentrations. Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. However, when atropine and oximes were used together we have obtained a potentiating and/or synergistic effect which was most significant with combination of atropine and TMB-4 giving up to a 15-fold decrease in the rate of aging reaction. The efficacy of this particular combination was concentration-dependent. We have also discussed similarities and differences in aging reaction occurring on NTE and AChE.en
dc.publisherElsevier Sci Ireland Ltd, Clare
dc.rightsrestrictedAccess
dc.sourceToxicology Letters
dc.subjectOrganophosphate-induced delayed polyneuropathy
dc.subjectOrganophosphates
dc.subjectOximes
dc.subjectAtropine
dc.titleModification of the rate of aging of diisopropylfluorophosphate-inhibited neuropathy target esterase of hen brainen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаксимовић, М; Косановић, М; Јокановић, М; Стојиљковић, Милош П.; Степановић-Петровић, Радица;
dc.citation.volume95
dc.citation.issue2
dc.citation.spage93
dc.citation.epage101
dc.citation.other95(2): 93-101
dc.citation.rankM22
dc.identifier.wos000074184100003
dc.identifier.doi10.1016/S0378-4274(98)00017-4
dc.identifier.pmid9635412
dc.identifier.scopus2-s2.0-0032536756
dc.type.versionpublishedVersion


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Приказ основних података о документу