Biopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorption
Abstract
Biopartitioning micellar chromatography (BMC), which is useful to mimic the drug partitioning process in biological systems, was used as a method for determination of partition coefficients micelle/water (P-m/w) of a set of structurally diverse drugs. BMC is a chromatographic system consisting of polyoxyethylene (23) lauryl ether (Brij 35) micellar mobile phase prepared in physiological conditions and C-18 reversed stationary phase. The retention factors were determined for all selected and studied compounds and a correlation between P-m/w and oral drug absorption values were obtained. In order to study the similarity between the BMC system and other natural systems of biomembranes, the retention data on BMC were compared with permeability data obtained in Parallel artificial membrane permeation assays (PAMPA lipid model). Molecular descriptors that are believed to influence trans-cellular transport and oral drug absorption have been calculated in order to obtain a predictive and relia...ble model for drug permeability. Results presented in this paper indicate that a proposed descriptor for hydrophobicity P-m/w, provided, from a statistical point of view, is a better model than other hydrophobicity descriptors.
Keywords:
Biopartitioning micellar chromatography / Oral absorption / Partition coefficientSource:
Analytical Letters, 2012, 45, 7, 677-688Publisher:
- Taylor & Francis Inc, Philadelphia
Funding / projects:
- Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-MESTD-Basic Research (BR or ON)-172041)
DOI: 10.1080/00032719.2011.653904
ISSN: 0003-2719
WoS: 000303820400004
Scopus: 2-s2.0-84861205362
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Institution/Community
PharmacyTY - JOUR AU - Čudina, Olivera AU - Marković, Bojan AU - Karljiković-Rajić, Katarina AU - Vladimirov, Sote PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1750 AB - Biopartitioning micellar chromatography (BMC), which is useful to mimic the drug partitioning process in biological systems, was used as a method for determination of partition coefficients micelle/water (P-m/w) of a set of structurally diverse drugs. BMC is a chromatographic system consisting of polyoxyethylene (23) lauryl ether (Brij 35) micellar mobile phase prepared in physiological conditions and C-18 reversed stationary phase. The retention factors were determined for all selected and studied compounds and a correlation between P-m/w and oral drug absorption values were obtained. In order to study the similarity between the BMC system and other natural systems of biomembranes, the retention data on BMC were compared with permeability data obtained in Parallel artificial membrane permeation assays (PAMPA lipid model). Molecular descriptors that are believed to influence trans-cellular transport and oral drug absorption have been calculated in order to obtain a predictive and reliable model for drug permeability. Results presented in this paper indicate that a proposed descriptor for hydrophobicity P-m/w, provided, from a statistical point of view, is a better model than other hydrophobicity descriptors. PB - Taylor & Francis Inc, Philadelphia T2 - Analytical Letters T1 - Biopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorption VL - 45 IS - 7 SP - 677 EP - 688 DO - 10.1080/00032719.2011.653904 ER -
@article{ author = "Čudina, Olivera and Marković, Bojan and Karljiković-Rajić, Katarina and Vladimirov, Sote", year = "2012", abstract = "Biopartitioning micellar chromatography (BMC), which is useful to mimic the drug partitioning process in biological systems, was used as a method for determination of partition coefficients micelle/water (P-m/w) of a set of structurally diverse drugs. BMC is a chromatographic system consisting of polyoxyethylene (23) lauryl ether (Brij 35) micellar mobile phase prepared in physiological conditions and C-18 reversed stationary phase. The retention factors were determined for all selected and studied compounds and a correlation between P-m/w and oral drug absorption values were obtained. In order to study the similarity between the BMC system and other natural systems of biomembranes, the retention data on BMC were compared with permeability data obtained in Parallel artificial membrane permeation assays (PAMPA lipid model). Molecular descriptors that are believed to influence trans-cellular transport and oral drug absorption have been calculated in order to obtain a predictive and reliable model for drug permeability. Results presented in this paper indicate that a proposed descriptor for hydrophobicity P-m/w, provided, from a statistical point of view, is a better model than other hydrophobicity descriptors.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Analytical Letters", title = "Biopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorption", volume = "45", number = "7", pages = "677-688", doi = "10.1080/00032719.2011.653904" }
Čudina, O., Marković, B., Karljiković-Rajić, K.,& Vladimirov, S.. (2012). Biopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorption. in Analytical Letters Taylor & Francis Inc, Philadelphia., 45(7), 677-688. https://doi.org/10.1080/00032719.2011.653904
Čudina O, Marković B, Karljiković-Rajić K, Vladimirov S. Biopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorption. in Analytical Letters. 2012;45(7):677-688. doi:10.1080/00032719.2011.653904 .
Čudina, Olivera, Marković, Bojan, Karljiković-Rajić, Katarina, Vladimirov, Sote, "Biopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorption" in Analytical Letters, 45, no. 7 (2012):677-688, https://doi.org/10.1080/00032719.2011.653904 . .