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dc.creatorČudina, Olivera
dc.creatorMarković, Bojan
dc.creatorKarljiković-Rajić, Katarina
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:30:09Z
dc.date.available2019-09-02T11:30:09Z
dc.date.issued2012
dc.identifier.issn0003-2719
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1750
dc.description.abstractBiopartitioning micellar chromatography (BMC), which is useful to mimic the drug partitioning process in biological systems, was used as a method for determination of partition coefficients micelle/water (P-m/w) of a set of structurally diverse drugs. BMC is a chromatographic system consisting of polyoxyethylene (23) lauryl ether (Brij 35) micellar mobile phase prepared in physiological conditions and C-18 reversed stationary phase. The retention factors were determined for all selected and studied compounds and a correlation between P-m/w and oral drug absorption values were obtained. In order to study the similarity between the BMC system and other natural systems of biomembranes, the retention data on BMC were compared with permeability data obtained in Parallel artificial membrane permeation assays (PAMPA lipid model). Molecular descriptors that are believed to influence trans-cellular transport and oral drug absorption have been calculated in order to obtain a predictive and reliable model for drug permeability. Results presented in this paper indicate that a proposed descriptor for hydrophobicity P-m/w, provided, from a statistical point of view, is a better model than other hydrophobicity descriptors.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceAnalytical Letters
dc.subjectBiopartitioning micellar chromatographyen
dc.subjectOral absorptionen
dc.subjectPartition coefficienten
dc.titleBiopartitioning Micellar Chromatography-Partition Coefficient Micelle/Water as a Potential Descriptor for Hydrophobicity in Prediction of Oral Drug Absorptionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВладимиров, Соте; Чудина, Оливера; Карљиковић-Рајић, Катарина; Марковић, Бојан;
dc.citation.volume45
dc.citation.issue7
dc.citation.spage677
dc.citation.epage688
dc.citation.other45(7): 677-688
dc.citation.rankM23
dc.identifier.wos000303820400004
dc.identifier.doi10.1080/00032719.2011.653904
dc.identifier.scopus2-s2.0-84861205362
dc.identifier.rcubconv_2632
dc.type.versionpublishedVersion


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