Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention
Само за регистроване кориснике
2012
Аутори
Stanković, SanjaAšanin, Milika
Trifunović, Danijela
Majkić-Singh, Nada
Ignjatović, Svetlana
Mrdović, Igor
Matić, Dragan
Savić, Lidija
Marinković, Jelena
Ostojić, Miodrag
Vasiljević, Zorana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objectives: To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI). Design and methods: A total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24,48 and 168 hours (h) after pPCI. Results: MPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at 4 h and 2411 after pPCI. In-hospital mortality was 6%. MPO at 24 h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24 h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13-9.86, P = 0.029). Conclusions: In patients with the first anterior STEMI treated by pPCI. MPO at 24 h after procedure was an i...ndependent predictor of the in-hospital mortality.
Кључне речи:
Myeloperoxidase / Primary percutaneous coronary intervention / Prognosis / STEMIИзвор:
Clinical Biochemistry, 2012, 45, 7-8, 547-551Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Биомаркери оштећења и дисфункције органа (RS-MESTD-Basic Research (BR or ON)-175036)
DOI: 10.1016/j.clinbiochem.2012.02.015
ISSN: 0009-9120
PubMed: 22394459
WoS: 000303553300007
Scopus: 2-s2.0-84860213581
Институција/група
PharmacyTY - JOUR AU - Stanković, Sanja AU - Ašanin, Milika AU - Trifunović, Danijela AU - Majkić-Singh, Nada AU - Ignjatović, Svetlana AU - Mrdović, Igor AU - Matić, Dragan AU - Savić, Lidija AU - Marinković, Jelena AU - Ostojić, Miodrag AU - Vasiljević, Zorana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1752 AB - Objectives: To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI). Design and methods: A total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24,48 and 168 hours (h) after pPCI. Results: MPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at 4 h and 2411 after pPCI. In-hospital mortality was 6%. MPO at 24 h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24 h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13-9.86, P = 0.029). Conclusions: In patients with the first anterior STEMI treated by pPCI. MPO at 24 h after procedure was an independent predictor of the in-hospital mortality. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention VL - 45 IS - 7-8 SP - 547 EP - 551 DO - 10.1016/j.clinbiochem.2012.02.015 ER -
@article{ author = "Stanković, Sanja and Ašanin, Milika and Trifunović, Danijela and Majkić-Singh, Nada and Ignjatović, Svetlana and Mrdović, Igor and Matić, Dragan and Savić, Lidija and Marinković, Jelena and Ostojić, Miodrag and Vasiljević, Zorana", year = "2012", abstract = "Objectives: To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI). Design and methods: A total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24,48 and 168 hours (h) after pPCI. Results: MPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at 4 h and 2411 after pPCI. In-hospital mortality was 6%. MPO at 24 h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24 h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13-9.86, P = 0.029). Conclusions: In patients with the first anterior STEMI treated by pPCI. MPO at 24 h after procedure was an independent predictor of the in-hospital mortality.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention", volume = "45", number = "7-8", pages = "547-551", doi = "10.1016/j.clinbiochem.2012.02.015" }
Stanković, S., Ašanin, M., Trifunović, D., Majkić-Singh, N., Ignjatović, S., Mrdović, I., Matić, D., Savić, L., Marinković, J., Ostojić, M.,& Vasiljević, Z.. (2012). Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 45(7-8), 547-551. https://doi.org/10.1016/j.clinbiochem.2012.02.015
Stanković S, Ašanin M, Trifunović D, Majkić-Singh N, Ignjatović S, Mrdović I, Matić D, Savić L, Marinković J, Ostojić M, Vasiljević Z. Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. in Clinical Biochemistry. 2012;45(7-8):547-551. doi:10.1016/j.clinbiochem.2012.02.015 .
Stanković, Sanja, Ašanin, Milika, Trifunović, Danijela, Majkić-Singh, Nada, Ignjatović, Svetlana, Mrdović, Igor, Matić, Dragan, Savić, Lidija, Marinković, Jelena, Ostojić, Miodrag, Vasiljević, Zorana, "Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention" in Clinical Biochemistry, 45, no. 7-8 (2012):547-551, https://doi.org/10.1016/j.clinbiochem.2012.02.015 . .