Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach
Samo za registrovane korisnike
2012
Autori
Rakić, TijanaMalenović, Anđelija
Jančić-Stojanović, Biljana
Ivanović, Darko
Medenica, Mirjana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The algorithm of Dong and error estimation based on a priori declared negligible effects (dummy factor effects approach) were evaluated for testing robustness, in case they provide contradictory results. Robustness of LC method for separation of ropinirole and its impurity was determined. Plackett-Burman design was applied to unravel the significant/influential factors. Four selected responses (retention factor of ropinirole and impurity, selectivity and resolution) were analyzed by the standard algorithm of Dong and dummy factor effects approach. The interpretation of the results for retention factor of ropinirole and resolution was inconclusive, since the two applied approaches identified different significant factors. The potential false negative or false positive results were avoided reanalyzing the results by the modified approaches. Modification of the dummy factor effects approach included omitting the large dummy effects values, and modification of the algorithm of Dong include...d calculating the margin of error values for all different number of factors included, and then selecting the lowest one to be the critical effect. The applied reanalysis allowed final important factor identification and non-significant intervals for significant effects calculation.
Ključne reči:
Modified algorithm of Dong / Robustness / Plackett-Burman design / Ropinirole / Column liquid chromatographyIzvor:
Chromatographia, 2012, 75, 7-8, 397-401Izdavač:
- Springer Heidelberg, Heidelberg
Finansiranje / projekti:
- Modelovanje različitih hromatografskih sistema sa hemometrijskim pristupom u farmaceutskoj analizi (RS-MESTD-Basic Research (BR or ON)-172052)
DOI: 10.1007/s10337-012-2196-6
ISSN: 0009-5893
WoS: 000303349400010
Scopus: 2-s2.0-84862873637
Institucija/grupa
PharmacyTY - JOUR AU - Rakić, Tijana AU - Malenović, Anđelija AU - Jančić-Stojanović, Biljana AU - Ivanović, Darko AU - Medenica, Mirjana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1758 AB - The algorithm of Dong and error estimation based on a priori declared negligible effects (dummy factor effects approach) were evaluated for testing robustness, in case they provide contradictory results. Robustness of LC method for separation of ropinirole and its impurity was determined. Plackett-Burman design was applied to unravel the significant/influential factors. Four selected responses (retention factor of ropinirole and impurity, selectivity and resolution) were analyzed by the standard algorithm of Dong and dummy factor effects approach. The interpretation of the results for retention factor of ropinirole and resolution was inconclusive, since the two applied approaches identified different significant factors. The potential false negative or false positive results were avoided reanalyzing the results by the modified approaches. Modification of the dummy factor effects approach included omitting the large dummy effects values, and modification of the algorithm of Dong included calculating the margin of error values for all different number of factors included, and then selecting the lowest one to be the critical effect. The applied reanalysis allowed final important factor identification and non-significant intervals for significant effects calculation. PB - Springer Heidelberg, Heidelberg T2 - Chromatographia T1 - Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach VL - 75 IS - 7-8 SP - 397 EP - 401 DO - 10.1007/s10337-012-2196-6 ER -
@article{ author = "Rakić, Tijana and Malenović, Anđelija and Jančić-Stojanović, Biljana and Ivanović, Darko and Medenica, Mirjana", year = "2012", abstract = "The algorithm of Dong and error estimation based on a priori declared negligible effects (dummy factor effects approach) were evaluated for testing robustness, in case they provide contradictory results. Robustness of LC method for separation of ropinirole and its impurity was determined. Plackett-Burman design was applied to unravel the significant/influential factors. Four selected responses (retention factor of ropinirole and impurity, selectivity and resolution) were analyzed by the standard algorithm of Dong and dummy factor effects approach. The interpretation of the results for retention factor of ropinirole and resolution was inconclusive, since the two applied approaches identified different significant factors. The potential false negative or false positive results were avoided reanalyzing the results by the modified approaches. Modification of the dummy factor effects approach included omitting the large dummy effects values, and modification of the algorithm of Dong included calculating the margin of error values for all different number of factors included, and then selecting the lowest one to be the critical effect. The applied reanalysis allowed final important factor identification and non-significant intervals for significant effects calculation.", publisher = "Springer Heidelberg, Heidelberg", journal = "Chromatographia", title = "Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach", volume = "75", number = "7-8", pages = "397-401", doi = "10.1007/s10337-012-2196-6" }
Rakić, T., Malenović, A., Jančić-Stojanović, B., Ivanović, D.,& Medenica, M.. (2012). Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach. in Chromatographia Springer Heidelberg, Heidelberg., 75(7-8), 397-401. https://doi.org/10.1007/s10337-012-2196-6
Rakić T, Malenović A, Jančić-Stojanović B, Ivanović D, Medenica M. Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach. in Chromatographia. 2012;75(7-8):397-401. doi:10.1007/s10337-012-2196-6 .
Rakić, Tijana, Malenović, Anđelija, Jančić-Stojanović, Biljana, Ivanović, Darko, Medenica, Mirjana, "Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach" in Chromatographia, 75, no. 7-8 (2012):397-401, https://doi.org/10.1007/s10337-012-2196-6 . .