ФарФаР - Фармацеутски факултет, репозиторијум
Универзитет у Београду, Фармацеутски факултет
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед рада 
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
  •   ФарФаР - Фармацеутски факултет, репозиторијум
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Преглед рада
JavaScript is disabled for your browser. Some features of this site may not work without it.

Comparative pharmacokinetics and bioavailability of two cotrimoxazole preparations

Нема приказа
Аутори
Pokrajac, Milena
Miljković, Branislava
Simić, D
Brzaković, B
Galetin, A
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
The objective of this study was to assess both pharmacokinetic properties and bioavailability of a newly developed cotrimoxazole preparation (Bioprim(R) tablets, 80 mg of trimethoprim/400 mg sulfamethoxazole), in comparison with a reference preparation commercially available (Bactrim(R) tablets, 80 mg of trimethoprim/400 mg of sulfamethoxazole). The pharmacokinetics and bioavailability of cotrimoxazole from these preparations were compared in an open randomized crossover study in 12 healthy males. Plasma concentrations of trimethoprim and sulfamethoxazole were measured by HPLC after protein precipitation. Noncompartmental pharmacokinetic analysis was performed on the plasma concentration-time data. The obtained pharmacokinetic values (C-max, t(max), beta, t(1/2)(beta), CL, V-d, AUC36, AUC(infinity)) of both trimethoprim and sulfamethoxazole determined in our study agreed with values reported in the literature. Westlake's and Nonparametric probability tests with the 90% confidence inter...vals, for both trimethoprim and sulfamethoxazole gave the differences within 80 and 120%, for all necessary measures (C-max, t(max) and AUC(infinity)). Statistical analysis of the data has shown that the preparations have similar pharmacokinetic profiles and therefore can be considered equally bioavailable.

Извор:
Pharmazie, 1998, 53, 7, 470-472
Издавач:
  • Govi-Verlag Gmbh, Eschborn

ISSN: 0031-7144

PubMed: 9699223

WoS: 000075161800010

Scopus: 2-s2.0-0031821076
[ Google Scholar ]
6
5
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/175
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB
 

 

Комплетан репозиторијумИнституцијеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О ФарФаР-у | Пошаљите запажања

OpenAIRERCUB