FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Dyslipidemia and oxidative stress in sarcoidosis patients

Authorized Users Only
2012
Authors
Ivanišević, Jasmina
Kotur-Stevuljević, Jelena
Stefanović, Aleksandra
Jelić-Ivanović, Zorana
Spasić, Slavica
Videnović-Ivanov, Jelica
Vučinić-Mihailović, Violeta
Ilić, Jasmina
Article (Published version)
Metadata
Show full item record
Abstract
Objectives: Sarcoidosis is an inflammatory disease characterised by enhanced production of reactive oxygen species and alterations in the circulating lipid profile. Both attributes are thought to play a role in its pathogenesis. However, current knowledge regarding the significance of blood oxidative stress/anti-oxidant defence as well as alterations in lipid status parameters in sarcoidosis is scarce. The aim of our study was to assess these parameters and their inter-relationships, as well as their potential for patient-control discrimination. Design and methods: Oxidative stress status and anti-oxidant defence parameters were determined in serum and erythrocytes and lipid status parameters were assessed in the serum of 213 treated sarcoidosis patients and 90 controls. Results: Malondialdehyde, superoxide anion, total oxidant status, prooxidant-antioxidant balance and triglycerides were significantly higher whereas total anti-oxidant status, superoxide dismutase activity and HDL-chol...esterol were significantly lower in sarcoidosis patients compared with controls. Total sulfhydryl group content was higher in patients compared with controls. Serum and erythrocyte malondialdehyde exhibited the strongest ability to predict disease presence. Elevated oxidative stress was characterised by higher clinical accuracy compared with lipid status abnormality. Some oxidative stress and lipid status markers were significantly associated in sarcoidosis. Conclusions: Sarcoidosis is characterised by increased oxidative stress, diminished overall anti-oxidative protection and alterations in the circulating lipid profile. Both oxidative stress and lipid status parameters demonstrated the potential to discriminate sarcoidosis from controls which was particularly evident from the point of view of oxidative stress status parameters. Association between these parameters may indicate an increased risk for atherosclerosis development.

Keywords:
Lipoprotein status / Oxidative stress status / Sarcoidosis
Source:
Clinical Biochemistry, 2012, 45, 9, 677-682
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1016/j.clinbiochem.2012.03.009

ISSN: 0009-9120

PubMed: 22449334

WoS: 000305169100016

Scopus: 2-s2.0-84861235704
[ Google Scholar ]
22
21
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1762
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
AU  - Videnović-Ivanov, Jelica
AU  - Vučinić-Mihailović, Violeta
AU  - Ilić, Jasmina
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1762
AB  - Objectives: Sarcoidosis is an inflammatory disease characterised by enhanced production of reactive oxygen species and alterations in the circulating lipid profile. Both attributes are thought to play a role in its pathogenesis. However, current knowledge regarding the significance of blood oxidative stress/anti-oxidant defence as well as alterations in lipid status parameters in sarcoidosis is scarce. The aim of our study was to assess these parameters and their inter-relationships, as well as their potential for patient-control discrimination. Design and methods: Oxidative stress status and anti-oxidant defence parameters were determined in serum and erythrocytes and lipid status parameters were assessed in the serum of 213 treated sarcoidosis patients and 90 controls. Results: Malondialdehyde, superoxide anion, total oxidant status, prooxidant-antioxidant balance and triglycerides were significantly higher whereas total anti-oxidant status, superoxide dismutase activity and HDL-cholesterol were significantly lower in sarcoidosis patients compared with controls. Total sulfhydryl group content was higher in patients compared with controls. Serum and erythrocyte malondialdehyde exhibited the strongest ability to predict disease presence. Elevated oxidative stress was characterised by higher clinical accuracy compared with lipid status abnormality. Some oxidative stress and lipid status markers were significantly associated in sarcoidosis. Conclusions: Sarcoidosis is characterised by increased oxidative stress, diminished overall anti-oxidative protection and alterations in the circulating lipid profile. Both oxidative stress and lipid status parameters demonstrated the potential to discriminate sarcoidosis from controls which was particularly evident from the point of view of oxidative stress status parameters. Association between these parameters may indicate an increased risk for atherosclerosis development.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Dyslipidemia and oxidative stress in sarcoidosis patients
VL  - 45
IS  - 9
SP  - 677
EP  - 682
DO  - 10.1016/j.clinbiochem.2012.03.009
ER  - 
@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Jelić-Ivanović, Zorana and Spasić, Slavica and Videnović-Ivanov, Jelica and Vučinić-Mihailović, Violeta and Ilić, Jasmina",
year = "2012",
abstract = "Objectives: Sarcoidosis is an inflammatory disease characterised by enhanced production of reactive oxygen species and alterations in the circulating lipid profile. Both attributes are thought to play a role in its pathogenesis. However, current knowledge regarding the significance of blood oxidative stress/anti-oxidant defence as well as alterations in lipid status parameters in sarcoidosis is scarce. The aim of our study was to assess these parameters and their inter-relationships, as well as their potential for patient-control discrimination. Design and methods: Oxidative stress status and anti-oxidant defence parameters were determined in serum and erythrocytes and lipid status parameters were assessed in the serum of 213 treated sarcoidosis patients and 90 controls. Results: Malondialdehyde, superoxide anion, total oxidant status, prooxidant-antioxidant balance and triglycerides were significantly higher whereas total anti-oxidant status, superoxide dismutase activity and HDL-cholesterol were significantly lower in sarcoidosis patients compared with controls. Total sulfhydryl group content was higher in patients compared with controls. Serum and erythrocyte malondialdehyde exhibited the strongest ability to predict disease presence. Elevated oxidative stress was characterised by higher clinical accuracy compared with lipid status abnormality. Some oxidative stress and lipid status markers were significantly associated in sarcoidosis. Conclusions: Sarcoidosis is characterised by increased oxidative stress, diminished overall anti-oxidative protection and alterations in the circulating lipid profile. Both oxidative stress and lipid status parameters demonstrated the potential to discriminate sarcoidosis from controls which was particularly evident from the point of view of oxidative stress status parameters. Association between these parameters may indicate an increased risk for atherosclerosis development.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Dyslipidemia and oxidative stress in sarcoidosis patients",
volume = "45",
number = "9",
pages = "677-682",
doi = "10.1016/j.clinbiochem.2012.03.009"
}
Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Jelić-Ivanović, Z., Spasić, S., Videnović-Ivanov, J., Vučinić-Mihailović, V.,& Ilić, J.. (2012). Dyslipidemia and oxidative stress in sarcoidosis patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(9), 677-682.
https://doi.org/10.1016/j.clinbiochem.2012.03.009
Ivanišević J, Kotur-Stevuljević J, Stefanović A, Jelić-Ivanović Z, Spasić S, Videnović-Ivanov J, Vučinić-Mihailović V, Ilić J. Dyslipidemia and oxidative stress in sarcoidosis patients. in Clinical Biochemistry. 2012;45(9):677-682.
doi:10.1016/j.clinbiochem.2012.03.009 .
Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Jelić-Ivanović, Zorana, Spasić, Slavica, Videnović-Ivanov, Jelica, Vučinić-Mihailović, Violeta, Ilić, Jasmina, "Dyslipidemia and oxidative stress in sarcoidosis patients" in Clinical Biochemistry, 45, no. 9 (2012):677-682,
https://doi.org/10.1016/j.clinbiochem.2012.03.009 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB