Analytical applications of oscillatory chemical reactions: Determination of some pharmaceutically and biologically important compounds

Abstract

Novel analytical methods for quantitive determination of analytes based on perturbations of oscillatory chemical reactions realized under open reactor conditions (continuosly fed well stirred tank reactor, CSTR), have been developed in the past twenty years. The proposed kinetic methods are generally based on the ability of the analyzed substances to change the kinetics of the chemical reactions matrix. The unambiguous correlation of quantitative characteristics of perturbations, and the amount (concentration) of analyte expressed as a regression equation, or its graphics (calibration curve), enable the determination of the unknown analyte concentration. Attention is given to the development of these methods because of their simple experimental procedures, broad range of linear regression (10-7-10-4 mol L-1) and low limits of detection of analytes (10-6-10-8 mol L-1, in some cases even lower than 10-12 mol L-1). Therefore, their application is very convenient for routine analysis of various inorganic and organic compounds as well as gases. This review summarizes progress made in the past 5 years on quantitative determination of pharmaceutically and biologically important compounds.

U poslednjih dvadesetak godina razvijene su brojne analitičke primene oscilatornih hemijskih reakcija realizovanih u otvorenom reaktoru. Predložene kinetičke metode se zasnivaju na sposobnosti analiziranih supstancija da menjaju kinetičke parametre hemijskih reakcija, pri čemu eksperimentalno dobijeni signal odražava reakcionu brzinu koja zavisi od koncentracije ispitivanog analita. Razvoju ovih metoda poklanja se sve veća pažnja zbog jednostavne eksperimentalne procedure, velikog linearnog opsega regresione jednačine (10-7-10-4 mol L-1) i niskog limita detekcije (10-6-10-8 mol L-1, u nekim slučajevima, ? 10-12 mol L-1), a njihovo korišćenje je vrlo pogodno za rutinske analize različitih neorganskih i organskih jedinjenja, kao i gasova. Ovaj rad ima za cilj da dâ kratki pregled primene takozvane pulsne perturbacione tehnike za kvantitativna određivanja nekih farmaceutski i biološki važnih jedinjenja u periodu od druge polovine 2005. godine do prve polovine 2011. godine.