Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method
Određivanje lizinoprila u farmaceutskim preparatima primenom kinetičke spektrofotometrijske metode
Apstrakt
A kinetic spectrophotometric method for determination of lisinopril in pharmaceuticals has been developed. The method is based on the activator action of lisinopril on Cu(II) ions catalysing the oxidation of Nile Blue A with hydrogen peroxide in borate buffer (pH 9.3). A decrease of the absorbance was recorded at 635 nm after 5 min at 25 °C. Linearity was established by application of the tangent method within the concentration range of lisinopril from 0.8-6.4 μg mL-1, the detection and quantification limits being 0.158 and 0.480 μg mL-1, respectively. The method was successfully applied to three brands of tablets containing lisinopril alone or in combination with hydrochlorothiazide.
Razvijena je kinetička spektrofotometrijska metoda za određivanje lizinoprila u farmaceutskim preparatima. Metoda se zasniva na aktivatorskom dejstvu lizinoprila na reakciju oksidacije boje nil plavog-A vodonik-peroksidom u boratnom puferu (pH 9,3), a koja je katalizovana Cu(II) jonima. Smanjenje apsorbancije mereno je na 635 nm u vremenskom periodu od 5 min na temperaturi 25°C. Linearnost je utvrđena primenom metode tangensa u opsegu koncentracija lizinoprila 0,8-6,4 μg mL-1, sa limitom detekcije 0,158 μg mL-1 i limitom određivanja 0,480 μg mL-1. Metoda je primenjena za analizu tri komercijalna preparata koja su sadržala lizinopril i lizinopril u kombinaciji sa hidrohlortiazidom.
Ključne reči:
lisinopril / Nile Blue A / spectrophotometry / kinetic determination / pharmaceuticalsIzvor:
Journal of the Serbian Chemical Society, 2012, 77, 10, 1437-1442Izdavač:
- Srpsko hemijsko društvo, Beograd
Finansiranje / projekti:
- Sinteza, kvantitativni odnos između strukture i dejstva, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (RS-MESTD-Basic Research (BR or ON)-172033)
DOI: 10.2298/JSC120131079C
ISSN: 0352-5139
WoS: 000311594100011
Scopus: 2-s2.0-84870215614
Institucija/grupa
PharmacyTY - JOUR AU - Čakar, Mira AU - Popović, Gordana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1822 AB - A kinetic spectrophotometric method for determination of lisinopril in pharmaceuticals has been developed. The method is based on the activator action of lisinopril on Cu(II) ions catalysing the oxidation of Nile Blue A with hydrogen peroxide in borate buffer (pH 9.3). A decrease of the absorbance was recorded at 635 nm after 5 min at 25 °C. Linearity was established by application of the tangent method within the concentration range of lisinopril from 0.8-6.4 μg mL-1, the detection and quantification limits being 0.158 and 0.480 μg mL-1, respectively. The method was successfully applied to three brands of tablets containing lisinopril alone or in combination with hydrochlorothiazide. AB - Razvijena je kinetička spektrofotometrijska metoda za određivanje lizinoprila u farmaceutskim preparatima. Metoda se zasniva na aktivatorskom dejstvu lizinoprila na reakciju oksidacije boje nil plavog-A vodonik-peroksidom u boratnom puferu (pH 9,3), a koja je katalizovana Cu(II) jonima. Smanjenje apsorbancije mereno je na 635 nm u vremenskom periodu od 5 min na temperaturi 25°C. Linearnost je utvrđena primenom metode tangensa u opsegu koncentracija lizinoprila 0,8-6,4 μg mL-1, sa limitom detekcije 0,158 μg mL-1 i limitom određivanja 0,480 μg mL-1. Metoda je primenjena za analizu tri komercijalna preparata koja su sadržala lizinopril i lizinopril u kombinaciji sa hidrohlortiazidom. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method T1 - Određivanje lizinoprila u farmaceutskim preparatima primenom kinetičke spektrofotometrijske metode VL - 77 IS - 10 SP - 1437 EP - 1442 DO - 10.2298/JSC120131079C ER -
@article{ author = "Čakar, Mira and Popović, Gordana", year = "2012", abstract = "A kinetic spectrophotometric method for determination of lisinopril in pharmaceuticals has been developed. The method is based on the activator action of lisinopril on Cu(II) ions catalysing the oxidation of Nile Blue A with hydrogen peroxide in borate buffer (pH 9.3). A decrease of the absorbance was recorded at 635 nm after 5 min at 25 °C. Linearity was established by application of the tangent method within the concentration range of lisinopril from 0.8-6.4 μg mL-1, the detection and quantification limits being 0.158 and 0.480 μg mL-1, respectively. The method was successfully applied to three brands of tablets containing lisinopril alone or in combination with hydrochlorothiazide., Razvijena je kinetička spektrofotometrijska metoda za određivanje lizinoprila u farmaceutskim preparatima. Metoda se zasniva na aktivatorskom dejstvu lizinoprila na reakciju oksidacije boje nil plavog-A vodonik-peroksidom u boratnom puferu (pH 9,3), a koja je katalizovana Cu(II) jonima. Smanjenje apsorbancije mereno je na 635 nm u vremenskom periodu od 5 min na temperaturi 25°C. Linearnost je utvrđena primenom metode tangensa u opsegu koncentracija lizinoprila 0,8-6,4 μg mL-1, sa limitom detekcije 0,158 μg mL-1 i limitom određivanja 0,480 μg mL-1. Metoda je primenjena za analizu tri komercijalna preparata koja su sadržala lizinopril i lizinopril u kombinaciji sa hidrohlortiazidom.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method, Određivanje lizinoprila u farmaceutskim preparatima primenom kinetičke spektrofotometrijske metode", volume = "77", number = "10", pages = "1437-1442", doi = "10.2298/JSC120131079C" }
Čakar, M.,& Popović, G.. (2012). Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 77(10), 1437-1442. https://doi.org/10.2298/JSC120131079C
Čakar M, Popović G. Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method. in Journal of the Serbian Chemical Society. 2012;77(10):1437-1442. doi:10.2298/JSC120131079C .
Čakar, Mira, Popović, Gordana, "Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method" in Journal of the Serbian Chemical Society, 77, no. 10 (2012):1437-1442, https://doi.org/10.2298/JSC120131079C . .